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CS 2100

4543 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4543/10
4543/50
CS 2100 | CAS No. 913827-99-3 | Sphingosine-1-phosphate Receptor Agonists
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Description: Selective S1P1 agonist

Chemical Name: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥97%

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Biological Activity

Sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.

Technical Data

M.Wt:
461.53
Formula:
C25H23N3O4S
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
913827-99-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
    Nakamura et al.
    Eur.J.Med.Chem., 2012;51:92
  2. Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
    Nakamura et al.
    Bioorg.Med.Chem.Lett., 2012;22:1788

Product Datasheets

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VersaClone cDNA Plasmids

Human S1P1/EDG-1 (NP_001391) VersaClone cDNA

RDC0052

Mouse S1P1/EDG-1 (NP_031927) VersaClone cDNA

RDC0053
1 Citations

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