CS 2100
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Description: Selective S1P1 agonist
Chemical Name: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥97%
Biological Activity
Sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.Technical Data
M.Wt:
461.53
Formula:
C25H23N3O4S
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
913827-99-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
Nakamura et al.
Eur.J.Med.Chem., 2012;51:92 -
Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
Nakamura et al.
Bioorg.Med.Chem.Lett., 2012;22:1788
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