CS 640

Key Product Details

Product Description

CS 640 is a potent calmodulin-dependent kinase I (CaMKI) inhibitor (IC₅₀ values are 1 nM, 1 nM, 3 nM and 8 nM at CAMK1A, CAMK1G, CAMK1B and CAMK1D respectively). Improves insulin sensitivity and glucose control in a mouse model of diet-induced obesity. Orally bioavailable in rodents.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the CS 640 probe summary on the SGC website.

Product Specifications for CS 640

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CS 640

The following data is based on the product molecular weight 397.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.58 mL	62.89 mL	125.78 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
2 mM	1.26 mL	6.29 mL	12.58 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fromont Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obesity in vivo mouse model. J.Med.Chem. 2020 PMID: 32433887

Product Documents for CS 640