CTAP

Tocris Bioscience | Catalog # 1560

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Citations (77)

Product Documents

Potent and selective μ antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective μ antagonist

View all mu Opioid Receptor Antagonists »

Product Description

CTAP is a potent and selective μ opioid receptor antagonist (IC₅₀ = 3.5 nM). Displays > 1200-fold selectivity over δ opioid and somatostatin receptors. Brain penetrant and active in vivo.

Product Specifications for CTAP

Molecular Weight

1104.32

Formula

C₅₁H₆₉N₁₃O₁₁S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

103429-32-9

PubChem ID

90479802

InChI Key

OFMQLVRLOGHAJI-KOFBULAQSA-N

SMILES

[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC(C)(C)C(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 77 publications citing the usage of this product.

Kramer Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo. J.Pharmacol.Exp.Ther. 1989 PMID: 2566679
Pelton Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. J.Med.Chem. 1986 PMID: 2878079
Abbruscato Blood-brain barrier permeability and bioavailability of a highly potent and μ-selective opioid receptor antagonist, CTAP: comparison with mor. J.Pharmacol.Exp.Ther. 1997 PMID: 8996221

Product Documents for CTAP

Certificate of Analysis

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Download SDS

Product Specific Notices for CTAP

For research use only

Citations for CTAP

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