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Description: Potent and selective μ antagonist

Purity: ≥95%

Product Details
Citations (13)
Supplemental Products

Biological Activity

CTAP is a potent and selective μ opioid receptor antagonist (IC50 = 3.5 nM). Displays > 1200-fold selectivity over δ opioid and somatostatin receptors. Brain penetrant and active in vivo.

Technical Data


(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = Pen, Disulfide bridge: 2-7, Thr-8 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CTAP

The citations listed below are publications that use Tocris products. Selected citations for CTAP include:

13 Citations: Showing 1 - 10

  1. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
    Authors: Birdsong Et al.
    Elife  2019;8
  2. MOR-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons.
    Authors: Nash Et al.
    Eneuro  2019;6
  3. Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity.
    Authors: Fox and Hentges
    J Neurosci  2017;37:8667
  4. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  5. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.
    Authors: Milan-Lobo Et al.
    PLoS One  2013;8:e58362
  6. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
    Authors: Largent-Milnes Et al.
    J Pharmacol Exp Ther  2013;347:7
  7. Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice.
    Authors: Maguma Et al.
    Eur J Pharmacol  2012;685:133
  8. Multiple inhibitory G-protein-coupled receptors resist acute desensitization in the presynaptic but not postsynaptic compartments of neurons.
    Authors: Pennock Et al.
    J Neurosci  2012;32:10192
  9. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
    Authors: Krook-Magnuson Et al.
    J Neurosci  2011;31:14861
  10. Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.
    Authors: Song Et al.
    J Biol Chem  2011;286:20354


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