CTOP

Catalog # Availability Size / Price Qty
1578/1
CTOP
1 Image
Description: Potent and selective μ antagonist
Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

Potent and selective μ opioid receptor antagonist (Ki values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K+ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.

Technical Data

M.Wt:
1062.28
Formula:
C50H67N11O11S2
Sequence:
FCYWXTXT

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X-5 = Orn, X-7 = Pen, Disulfide bridge between 2 - 7, Thr-8 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
103429-31-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CTOP

The citations listed below are publications that use Tocris products. Selected citations for CTOP include:

12 Citations: Showing 1 - 10

  1. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
    Authors: Nam Et al.
    Cell Rep  2019;28:1154
  2. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
    Authors: Stoeber Et al.
    Neuron  2018;98:963
  3. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  4. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins.
    Authors: Francois Et al.
    Neuron  2017;93:822
  5. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  6. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  7. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  8. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Mol Pharmacol  2011;31:13068
  9. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  10. Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.
    Authors: Choi Et al.
    Korean J Pain  2010;23:236

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