Catalog Number: 1578
Biological Activity
Potent and selective μ opioid receptor antagonist (Ki values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K+ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.
Technical Data
  • M.Wt:
    1062.28
  • Formula:
    C50H67N11O11S2
  • Sequence:
    FCYWXTXT

    (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X-5 = Orn, X-7 = Pen, Disulfide bridge between 2 - 7, Thr-8 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    103429-31-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity.
    Badiani et al.
    Brain Res., 1995;690:112
  2. Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
    Gulya et al.
    Eur.J.Pharmacol., 1988;150:355
  3. [3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain.
    Hawkins et al.
    J.Pharmacol.Exp.Ther., 1989;248:73
  4. The μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a no
    Chieng et al.
    Mol.Pharmacol., 1996;50:650
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CTOP include:

4 Citations: Showing 1 - 4
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  1. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  2. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Mol Pharmacol 2011;31:13068
  3. δ-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption.
    Authors: Margolis Et al.
    J Clin Immunol 2008;28:12672
  4. Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
    Authors: Börner Et al.
    J Neurosci 2006;69:1486
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