CTOP

  (4 citations)   
Catalog Number:1578
Product Details
Citations (4)
Reviews
Biological Activity
Potent and selective μ opioid receptor antagonist (Ki values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K+ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.
Technical Data
  • M.Wt:
    1062.28
  • Formula:
    C50H67N11O11S2
  • Sequence:
    FCYWXTXT

    (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X-5 = Orn, X-7 = Pen, Disulfide bridge between 2 - 7, Thr-8 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    103429-31-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CTOP include:

4 Citations: Showing 1 - 4
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  1. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  2. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Mol Pharmacol  2011;31:13068
  3. δ-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption.
    Authors: Margolis Et al.
    J Clin Immunol  2008;28:12672
  4. Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
    Authors: Börner Et al.
    J Neurosci  2006;69:1486

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