Cultrex Rat Collagen I, Lower Viscosity
Cultrex Rat Collagen I, Lower Viscosity Summary
• Qualified for general cell culture applications
• Lower in viscosity for easier handling
• May be used as a hydrogel or thin coating for tissue culture vessels
• Material provided at a standard concentration of ~3 mg/mL
Why Use Cultrex Rat Collagen I, Lower Viscosity?
Cultrex Rat Collagen I, Lower Viscosity is purified from rat tail tendons and is provided at a standard concentration that is lower in viscosity, making it easier to work with. Collagen I is the major structural component of extracellular matrices (ECM) found in connective tissue and internal organs, but is most prevalent in the dermis, tendons, and bone. It is a 300 kDa molecule composed of two alpha1(I) chains and one alpha2(I) chain that spontaneously forms a triple helix scaffold at a neutral pH and 37°C. This phenomenon can be exploited to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. To provide the most standardized Collagen I, a special process is employed to provide material at a standard concentration of approximately 3 mg/mL.
For research use only. Not for diagnositic use.
Citations for Cultrex Rat Collagen I, Lower Viscosity
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Boosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles
Authors: M Pinto, C Fernandes, E Martins, R Silva, S Benfeito, F Cagide, RF Mendes, FA Almeida Pa, J Garrido, F Remião, F Borges
Pharmaceutics, 2019;11(7):. 2019
Innovative in cellulo method as an alternative to in vivo neurovirulence test for the characterization and quality control of human live Yellow Fever virus vaccines: A pilot study
Authors: A da Costa, C Prehaud, C Khou, N Pardigon, A Saulnier, N Nougarede, M Lafon
Biologicals, 2018;0(0):. 2018
Assessing the Impact of Targeting CEACAM1 in Head and Neck Squamous Cell Carcinoma
Authors: K Tam, DW Schoppy, JH Shin, JK Tay, U Moreno-Nie, DC Mundy, JB Sunwoo
Otolaryngol Head Neck Surg, 2018;0(0):1945998187566. 2018
What is the difference between the standard Cultrex Rat Collagen I and the Cultrex 3-D Rat Collagen I?
Cultrex 3-D Rat Collagen I undergoes the same basic purification and efficacy tests as the standard collagen. However, it undergoes additional 3-D culture validation; it has been tested extensively for the ability to promote growth and differentiation of cell types, visualized by morphology in three dimensions in vitro.
What are the differences between Cultrex Rat Collagen I and Cultrex Rat Collagen I, Low Viscosity?
Cultrex Rat Collagen I is provided at 5 mg/mL and is not pepsin treated, so it has intact telopeptides and is highly viscous. Cultrex Rat Collagen I, Low Viscosity is provided at 3 mg/mL, and it is easier to pipet. Both are provided in acetic acid and require pH neutralization prior to use. Please consult the provided product data sheets for pH neutralization instructions.
Is Cultrex Rat Collagen I atelocollagen or telocollagen?
Cultrex Rat Collagen I is telocollagen.
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