Catalog Number: 2980
Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Biological Activity
AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546.
    Nagararjan et al.
    Neuropharmacology., 2001;41:650
  2. AMPA receptor potentiators for the treatment of CNS disorders.
    O'Neill et al.
    Curr.Drug Targets CNS Neurol.Disord., 2004;3:181
  3. Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats.
    Shimazaki et al.
    Eur.J.Pharmacol., 2007;575:94
  4. Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits.
    Huang et al.
    Sci.Transl.Med., 2016;8:ra85
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