Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Biological ActivityCX 546 is an AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits.
Huang et al.
Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546.
Nagararjan et al.
AMPA receptor potentiators for the treatment of CNS disorders.
O'Neill et al.
Curr.Drug Targets CNS Neurol.Disord., 2004;3:181
Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats.
Shimazaki et al.
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