CX 614

Key Product Details

Product Description

CX 614 is an AMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.

Product Specifications for CX 614

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CX 614

The following data is based on the product molecular weight 247.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.04 mL	20.22 mL	40.44 mL
5 mM	0.81 mL	4.04 mL	8.09 mL
10 mM	0.40 mL	2.02 mL	4.04 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Timm Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 2011 PMID: 21543522
• Hennegriff Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators. J.Neurochem. 1997 PMID: 9166736
• Harms Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology 2013 PMID: 22735771

Product Documents for CX 614