CY 208-243

Catalog # Availability Size / Price Qty
1249/10
1249/50
CY 208-243 | CAS No. 100999-26-6 | Dopamine D1 and D5 Receptor Agonists
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Description: Selective D1-like agonist

Chemical Name: (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin

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Biological Activity

CY 208-243 is a centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.

Technical Data

M.Wt:
274.36
Formula:
C19H18N2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
100999-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novartis Pharma AG

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. DA receptor agonists: selectivity and DA D1 receptor efficacy.
    Andersen and Jansen
    Eur.J.Pharmacol., 1990;188:335
  3. Antiparkinsonian activity of CY 208-243, a partial D-1 DA receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease.
    Temlett et al.
    Mov.Disord., 1989;4:261
  4. Pharmacologic properties of CY 208-243, a novel D1 agonist.
    Markstein et al.
    Progress in Catecholamine Research. Part B. Centra, 1988;:59-64

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