Centrally active dopamine D1
receptor agonist, selective over D2
receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50
of 125 nM. Unlike SKF 38393
(Cat. No. 0922), it exerts antiParkinsonian activity in animal models.
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Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy.
Andersen and Jansen
Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease.
Temlett et al.
Pharmacologic properties of CY 208-243, a novel D1 agonist.
Markstein et al.
Progress in Catecholamine Research. Part B. Centra, 1988;:59-64