CY 208-243

Key Product Details

Product Description

CY 208-243 is a centrally active dopamine D₁ receptor agonist, selective over D₂ receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC₅₀ of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.

Licensing Information

Sold with the permission of Novartis Pharma AG

Product Specifications for CY 208-243

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CY 208-243

The following data is based on the product molecular weight 274.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.64 mL	18.22 mL	36.45 mL
5 mM	0.73 mL	3.64 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.64 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Temlett Antiparkinsonian activity of CY 208-243, a partial D-1 DA receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 1989 PMID: 2571082
• Markstein Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra
• Andersen and Jansen DA receptor agonists: selectivity and DA D₁ receptor efficacy. Eur.J.Pharmacol. 1990 PMID: 1973652

Product Documents for CY 208-243