Catalog Number: 1249
Chemical Name: (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Biological Activity
Centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.
Technical Data
  • M.Wt:
    274.36
  • Formula:
    C19H18N2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    100999-26-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy.
    Andersen and Jansen
    Eur.J.Pharmacol., 1990;188:335
  2. Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease.
    Temlett et al.
    Mov.Disord., 1989;4:261
  3. Pharmacologic properties of CY 208-243, a novel D1 agonist.
    Markstein et al.
    Progress in Catecholamine Research. Part B. Centra, 1988;:59-64

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