Catalog Number: 3493
Alternate Names: Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])
Biological Activity
Non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.
Technical Data
  • M.Wt:
    779.98
  • Formula:
    C44H57N7O6
  • Sequence:
    FWKT

    (Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-1 = DTrp, Thr-4 = Bn-Thr)

  • Solubility:
    Soluble to 1 mg/ml in 20% ethanol / water
  • Storage:
    Store at -20°C
  • CAS No:
    84211-54-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat.
    Fries et al.
    Peptides, 1982;3:811
  2. The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist.
    Stirnweis et al.
    Peptides, 2002;23:1503
  3. Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat.
    Guo et al.
    Brain Res., 2008;1229:61
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cyclosomatostatin include:

1 Citations: Showing 1 - 1

  1. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab 2015;308:E130

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