Cyclosomatostatin

Name: Cyclosomatostatin
Brand: Tocris Bioscience
SKU: 3493
Price: 266 USD
Availability: InStock

Tocris Bioscience | Catalog # 3493

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Citations (19)

Product Documents

Non-selective sst antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Non-selective sst antagonist

Alternative Names

Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])

View all Somatostatin Receptor Antagonists »

Product Description

Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

Product Specifications for Cyclosomatostatin

Molecular Weight

779.98

Formula

C₄₄H₅₇N₇O₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

84211-54-1

PubChem ID

122080

InChI Key

YHVHQZYJGWGAKN-ZUWUZHNASA-N

SMILES

C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% ethanol / water

Calculators

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Mass

Concentration

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Stirnweis The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 2002 PMID: 12182954
Guo Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 2008 PMID: 18640104
Fries Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat. Peptides 1982 PMID: 6129618

Product Documents for Cyclosomatostatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Cyclosomatostatin

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Citations for Cyclosomatostatin

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