Catalog Number: 0713
Chemical Name: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide
Biological Activity
Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™.
Technical Data
  • M.Wt:
    389.87
  • Formula:
    C14H16ClN3O4S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    2259-96-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cyclothiazide acts at a site on the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognise competitive or noncompetitive AMPA receptor antagonists.
    Desai et al.
    J.Pharmacol.Exp.Ther., 1995;272:38
  2. Allosteric regulation of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benzodiazepines.
    Donevan and Rogawski
    Neuroscience, 1998;87:615
  3. The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits.
    Kessler et al.
    Neurosci.Lett., 2000;287:161
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cyclothiazide include:

14 Citations: Showing 1 - 10
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  1. Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
    Authors: Imlach Et al.
    Scientific Reports 2016;6:37104?
  2. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Neuropsychopharmacology 2015;9:409
  3. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    Front Cell Neurosci 2015;35:16171
  4. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    PLoS One 2015;10:e0131430
  5. Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A).
    Authors: Seebohm Et al.
    Pflugers Arch 2014;466:1885
  6. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
    Authors: Maguire Et al.
    PLoS One 2014;39:1232
  7. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    J Neurosci 2013;33:8336
  8. Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells.
    Authors: Oh Et al.
    PLoS One 2012;7:e47846
  9. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
    Authors: Kopach Et al.
    Pain 2011;152:912
  10. Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.
    Authors: Smejkalova and Woolley
    J Neurosci 2010;30:16137
  11. Critical role for TARPs in early development despite broad functional redundancy.
    Authors: Menuz Et al.
    Neuropharmacology 2009;56:22
  12. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.
    Authors: Soto Et al.
    Nat Neurosci 2009;12:277
  13. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
    Authors: Takayasu Et al.
    J Neurosci 2006;26:6563
  14. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci 2006;26:4166
Expand to show all 14 Citations

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