Cyclothiazide

Tocris Bioscience | Catalog # 0713

Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
Tocris Bioscience

Key Product Details

Description

Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
View all AMPA Receptor Modulators »

Product Description

Cyclothiazide is a positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits.

Product Specifications for Cyclothiazide

Molecular Weight

389.87

Formula

C14H16ClN3O4S2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide

CAS Number

2259-96-3

PubChem ID

2910

InChI Key

BOCUKUHCLICSIY-UHFFFAOYSA-N

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C1CC2CC1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.99 100
Ethanol 9.75 25

Preparing Stock Solutions for Cyclothiazide

The following data is based on the product molecular weight 389.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Product Documents for Cyclothiazide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cyclothiazide

For research use only

Customer Reviews for Cyclothiazide (2)

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  • Modulation of AMPA-receptor kinetics
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 12/22/2020
    Preparation of 10 mM ethanol stock requires sonication.
    Cyclothiazide was used to prevent desensitization of AMPA-receptors in hippocampal pyramidal neurons. The compound prolonged the decay time of multi-synaptic evoked excitatory currents in cell somata. No difference between effects at 22-25 C and 33-36 C was detected. Illustration, grey trace: control response normalized to response amplitude under cyclothiazide.
    Cyclothiazide 0713
  • effectively blocks desensitization of AMPA receptors
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: motor neurons
    Verified Customer | Posted 11/02/2018
    Used to prevent desensitization AMPA receptors in motor neurons. Used at concentration of 200 micromolar to measure whole cell current in motor neurons upon AMPA application.
    Cyclothiazide 0713

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