Cyclothiazide

Catalog # Availability Size / Price Qty
0713/10
0713/50
Cyclothiazide | CAS No. 2259-96-3 | AMPA Receptor Modulators
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Description: Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization

Chemical Name: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide

Purity: ≥98%

Product Details
Citations (21)
Reviews (1)

Biological Activity

Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits.

Technical Data

M.Wt:
389.87
Formula:
C14H16ClN3O4S2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
2259-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cyclothiazide

The citations listed below are publications that use Tocris products. Selected citations for Cyclothiazide include:

21 Citations: Showing 1 - 10

  1. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
    Authors: Fan Et al.
    Nat Methods  2018;15:823
  2. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.
    Authors: Bretin Et al.
    PLoS One  2017;12:e0184429
  3. Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
    Authors: Imlach Et al.
    Scientific Reports  2016;6:37104
  4. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Neuropsychopharmacology  2015;9:409
  5. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    Front Cell Neurosci  2015;35:16171
  6. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    PLoS One  2015;10:e0131430
  7. Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A).
    Authors: Seebohm Et al.
    Pflugers Arch  2014;466:1885
  8. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
    Authors: Maguire Et al.
    PLoS One  2014;39:1232
  9. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.
    Authors: Harms Et al.
    Neuropharmacology  2013;64:45
  10. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    J Neurosci  2013;33:8336
  11. Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells.
    Authors: Oh Et al.
    PLoS One  2012;7:e47846
  12. Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool.
    Authors: Lee Et al.
    Proc Natl Acad Sci U S A  2012;109:E765
  13. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
    Authors: Kopach Et al.
    Pain  2011;152:912
  14. OE acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.
    Authors: Smejkalova and Woolley
    J Neurosci  2010;30:16137
  15. Cyclothiazide induces seizure behavior in freely moving rats.
    Authors: Kong Et al.
    Brain Res  2010;1355:207
  16. Critical role for TARPs in early development despite broad functional redundancy.
    Authors: Menuz Et al.
    Neuropharmacology  2009;56:22
  17. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.
    Authors: Soto Et al.
    Nat Neurosci  2009;12:277
  18. Frequency-independent synaptic transmission supports a linear vestibular behavior.
    Authors: Bagnall Et al.
    Neuron  2008;60:343
  19. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
    Authors: Takayasu Et al.
    J Neurosci  2006;26:6563
  20. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci  2006;26:4166
  21. AMPA receptors are modulated by tachykinins in rat cerebellum neurons.
    Authors: Pieri Et al.
    J Neurophysiol  2005;94:2484

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effectively blocks desensitization of AMPA receptors
By Karthik krishnamurthy on 11/02/2018
Species: Rat

Used to prevent desensitization AMPA receptors in motor neurons. Used at concentration of 200 micromolar to measure whole cell current in motor neurons upon AMPA application.


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