Potent and selective sphingosine-1-phosphate receptor 4 (S1P4
) agonist (EC50
values are 56 nM and 2100 nM for S1P4
receptors, respectively). Displays no activity at S1P1
receptors at concentrations up to 25 μ
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.
Urbano et al.