Selective sphingosine-1-phosphate receptor 3 (S1P3
) allosteric agonist (EC50
= 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3
than S1P. Displays no activity at S1P1
receptors at concentrations up to 10 μ
M. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.
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All Tocris products are intended for laboratory research use only.
Novel selective allosteric and bitopic ligands for the S1P3 receptor.
Jo et al.
ACS Chem.Biol., 2012;7:1975
The citations listed below are publications that use Tocris products. Selected citations for CYM 5541 include:
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