CYM 5541

Catalog # Availability Size / Price Qty
CYM 5541 | CAS No. 945128-26-7 | Sphingosine-1-phosphate Receptor Agonists
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Description: Selective S1P3 receptor allosteric agonist

Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

Purity: ≥97%

Product Details
Citations (3)
Supplemental Products

Biological Activity

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel selective allosteric and bitopic ligands for the S1P3 receptor.
    Jo et al.
    ACS Chem.Biol., 2012;7:1975

Product Datasheets

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Citations for CYM 5541

The citations listed below are publications that use Tocris products. Selected citations for CYM 5541 include:

3 Citations: Showing 1 - 3


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