CYM 5541

Key Product Details

Product Description

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P₃) allosteric agonist (EC₅₀ = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P₃ than S1P. Displays no activity at S1P₁, S1P₂, S1P₄ and S1P₅ receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Product Specifications for CYM 5541

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CYM 5541

The following data is based on the product molecular weight 316.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.80 mL	31.60 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

• Jo Novel selective allosteric and bitopic ligands for the S1P₃ receptor. ACS Chem.Biol. 2012 PMID: 22971058

Product Documents for CYM 5541