The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, CysLTR1 and CysLTR2. Both receptors are members of the superfamily of G protein-coupled receptors. CysLTR2 seems to play a major role in endocrine and cardiovascular systems. Stimulation of CysLTR2 by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium.
Cysteinyl Leukotriene R2/CysLTR2 Recombinant Protein Antigen
Novus Biologicals | Catalog # NBP2-13897PEP
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Key Product Details
Source
E. coli
Applications
Antibody Competition
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Product Specifications
Description
A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human CYSLTR2.
Source: E. coli
Amino Acid Sequence: KFMSLQPSISVSEMEPNGTFSNNNSRNCTIE
Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)
This product is intended to be used as a blocking antigen for antibody competition assays. Any other use of this antigen is done at the risk of the user. The use of this product for commercial production is strictly prohibited. Please contact technical support if you have any questions.
Purity
>80% by SDS-PAGE and Coomassie blue staining
Predicted Molecular Mass
21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Applications
Antibody Competition (10 - 100 molar excess)
Application Notes
This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP2-13897.
It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.
For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com
Protein / Peptide Type
Recombinant Protein Antigen
Formulation, Preparation, and Storage
NBP2-13897PEP
| Formulation | PBS and 1M Urea, pH 7.4. |
| Preservative | No Preservative |
| Concentration | Please see the vial label for concentration. If unlisted please contact technical services. |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at -20C. Avoid freeze-thaw cycles. |
Background: Cysteinyl Leukotriene R2/CysLTR2
Long Name
Cysteinyl Leukotriene Receptor 2
Alternate Names
CysLT2, CysLTR2, Cysteinyl LeukotrieneR2, HG57, HPN321, KPG_011
Gene Symbol
CYSLTR2
Additional Cysteinyl Leukotriene R2/CysLTR2 Products
Product Documents for Cysteinyl Leukotriene R2/CysLTR2 Recombinant Protein Antigen
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Cysteinyl Leukotriene R2/CysLTR2 Recombinant Protein Antigen
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
Related Research Areas
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