Catalog Number: 1180
Biological Activity
Selective peptide agonist for the δ opioid receptor. Antinociceptive in vivo.
Technical Data
  • M.Wt:
    782.89
  • Formula:
    C38H54N8O10
  • Sequence:
    YAFEVVG

    (Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    122752-16-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationships of a series of [D-Ala2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.
    Thomas et al.
    J.Pharmacol.Exp.Ther., 1997;281:817
  2. Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception.
    Sanchez-Blazquez
    J.Pharmacol.Exp.Ther., 1998;285:820
  3. Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.
    Mattia et al.
    J.Pharmacol.Exp.Ther., 1991;258:583
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [D-Ala2]-Deltorphin II include:

3 Citations: Showing 1 - 3
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  1. Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    Authors: Schuster Et al.
    Arthritis Res Ther 2015;172:642
  2. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int 2013;13:93
  3. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
    Authors: Krook-Magnuson Et al.
    J Neurosci 2011;31:14861

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