Chemical Name: D-(-)-2-Amino-4-phosphonobutyric acid
Biological ActivityD-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.
DL Mixture and L-isomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378
Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203
Citations for D-AP4
The citations listed below are publications that use Tocris products. Selected citations for D-AP4 include:
3 Citations: Showing 1 - 3
Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
Authors: Sexton and Gelder
PLoS One 2015;10:e0128690
Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype.
Authors: Sexton Et al.
Neural Dev 2015;10:17
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