Catalog Number: 0102
Chemical Name: D-(-)-2-Amino-4-phosphonobutyric acid
Biological Activity

Broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.

DL Mixture and L-isomer also available.
Technical Data
  • M.Wt:
    183.1
  • Formula:
    C4H10NO5P
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    78739-01-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
    Davies and Watkins
    Brain Res., 1982;235:378
  2. The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
    Evans et al.
    Br.J.Pharmacol., 1982;75:65
  3. Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    Schulte et al.
    Brain Res., 1994;649:203
Citations:

The citations listed below are publications that use Tocris products. Selected citations for D-AP4 include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
    Authors: France
    Neuropharmacology 2017;112:76
  2. G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
    Authors: Sexton and Gelder
    PLoS One 2015;10:e0128690
  3. Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype.
    Authors: Sexton Et al.
    Neural Dev 2015;10:17

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