Catalog Number: 3377
Biological Activity
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
Technical Data
  • M.Wt:
    1151.38
  • Formula:
    C52H74N14O12S2
  • Sequence:
    YFQNCPRG

    (Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    73168-24-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vas
    Kruszynski et al.
    J.Med.Chem., 1980;23:364
  2. Arginine vasopressin and oxytocin increase intracellular calcium and cAMP in human glomerular epithelial cells in culture.
    Spath et al.
    Kidney Blood Press.Res., 1996;19:81
  3. Vasopressin inhibits sarcolemmal ATP-sensitive K+ channels via V1 receptors activation in the guinea pig heart.
    Tsuchiya et al.
    Circ.J., 2002;66:277
  4. Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus.
    Engin and Treit
    Neuropeptides, 2008;42:411

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