Biological Activity(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin is a selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
(Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide)
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Vasopressin inhibits sarcolemmal ATP-sensitive K+ channels via V1 receptors activation in the guinea pig heart.
Tsuchiya et al.
Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus.
Engin and Treit
Arginine vasopressin and oxyt. increase intracellular calcium and cAMP in human glomerular epithelial cells in culture.
Spath et al.
Kidney Blood Press.Res., 1996;19:81
[1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vas
Kruszynski et al.
Citation for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
The citations listed below are publications that use Tocris products. Selected citations for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin include:
1 Citation: Showing 1 - 1
Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors.
Authors: Campos-Lira Et al.
Front Neurosci 2019;12:919
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