D-GsMTx4

Tocris Bioscience | Catalog # 7170

TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
Tocris Bioscience

Key Product Details

Description

TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
View all TRPC Channel Blockers »

Product Description

D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Product Specifications for D-GsMTx4

Molecular Weight

4095.86

Formula

C185H273N49O45S6

Storage

Store at -20°C

Purity

≥95% (HPLC)

InChI Key

WVDNTWXIIKNMHY-CFGROZRMSA-N

SMILES

CC(C)C[C@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H]2CSSC[C@@H](NC(=O)CN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]3CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC1=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(N)=O)NC3=O)C(=O)N2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for D-GsMTx4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for D-GsMTx4

For research use only

Related Research Areas

Ion Channels and Regulators

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