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Description: TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion

Purity: ≥95%

Product Details

Biological Activity

D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.

Technical Data


(Modifications: All aminoacids = D-aminoacids, Disulfide bridges: 2-17, 9-23, 16-30, Phe-34 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Research Foundation of The State University of New York

Background References

  1. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4
    Bae et al.
    Biochemistry, 2011;50:6295
  2. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
    Alcaino et al.
    Channels (Austin), 2017;11:245
  3. Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1
    Maneshi et al.
    Sci. Rep., 2018;8:14267
  4. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels
    Gnanasambandam et al.
    Biophys.J., 2017;112:31

Product Datasheets

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