Biological ActivityTRPC1 and TRPC6 blocker. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
(Modifications: Disulfide bridge: 2-17,9-23,16-30)
(Modifications: Phe-34 = C-terminal amide)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.
Bae et al.
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.
Bowman et al.
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.
Suchyna et al.
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.
Drew et al.
PLoS One, 2007;2:e515
Citations for GsMTx4
The citations listed below are publications that use Tocris products. Selected citations for GsMTx4 include:
4 Citations: Showing 1 - 4
The mechanosensitive Piezo1 channel is required for bone formation.
Authors: Sun Et al.
Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1.
Authors: Wong Et al.
J Clin Med 2018;7
Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Authors: Dela Paz
Biochem Biophys Res Commun 2018;497(1):220
Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.
Authors: Agbani Et al.
JCI Insight 2018;3
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It blocks mechanosensitive channels such as TRPC1 and 6.Dissolved in artificial cerebrospinal fluid (acsf) at 20 microM.