Catalog Number: 4912
Biological Activity
TRPC1 and TRPC6 blocker. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
Technical Data
  • M.Wt:
    4095.86
  • Formula:
    C185H273N49O45S6
  • Sequence:
    GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF

    (Modifications: Disulfide bridge: 2-17,9-23,16-30)

    (Modifications: Phe-34 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The Research Foundation of The State University of New York
Background References
  1. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.
    Bowman et al.
    Toxicon., 2007;49:249
  2. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.
    Suchyna et al.
    J.Gen.Physiol., 2000;115:583
  3. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.
    Drew et al.
    PLoS One, 2007;2:e515

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