TRPC1 and TRPC6 blocker. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
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Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.
Bowman et al.
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.
Suchyna et al.
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.
Drew et al.
PLoS One, 2007;2:e515