GsMTx4

Tocris Bioscience | Catalog # 4912

TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels
Tocris Bioscience

Key Product Details

Description

TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels
View all TRPC Channel Blockers »

Product Description

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Product Specifications for GsMTx4

Molecular Weight

4095.86

Formula

C185H273N49O45S6

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1209500-46-8

PubChem ID

90488987

InChI Key

WVDNTWXIIKNMHY-UHFFFAOYSA-N

SMILES

[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Product Documents for GsMTx4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GsMTx4

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for GsMTx4 (1)

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  • a mechanosensitive channel blocker
    Name: Hyun Choi
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Applied to brain slices
    Verified Customer | Posted 02/19/2018
    It blocks mechanosensitive channels such as TRPC1 and 6. Dissolved in artificial cerebrospinal fluid (acsf) at 20 microM.

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