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Description: TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

Purity: ≥95%

Product Details
Citations (5)

Biological Activity

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.

Technical Data


(Modifications: Disulfide bridges: 2-17, 9-23, 16-30), Phe-34 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Research Foundation of The State University of New York

Product Datasheets

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Citations for GsMTx4

The citations listed below are publications that use Tocris products. Selected citations for GsMTx4 include:

5 Citations: Showing 1 - 5


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