Biological Activity[D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes.
Schioth et al.
Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus.
Traebert et al.
Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids.
Pinilla et al.
Citations for [D-Lys3]-GHRP-6
The citations listed below are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:
6 Citations: Showing 1 - 6
Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.
Authors: Murtuza and Isokawa
J Neurochem 2018;144:58
Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.
Authors: Kamei Et al.
PLoS One 2017;12:e0171819
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
PLoS One 2017;12(9):e0184261
The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice.
Authors: Gomez and
Alcohol Clin Exp Res 2014;38:2436
Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion.
Authors: Song Et al.
PLoS One 2013;8:e65422
Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats.
Authors: Kemp Et al.
PLoS Comput Biol 2011;57:633
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