Catalog Number: 1922
Biological Activity
Antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)

  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes.
    Schioth et al.
    Neuropeptides, 1997;31:565
  2. Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus.
    Traebert et al.
    J.Neuroendocrinol., 2002;14:580
  3. Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids.
    Pinilla et al.
    Neuroendocrinology, 2003;77:83

The citations listed below are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:

Showing Results 1 - 2 of 2

  1. The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice.
    Authors: Gomez and
    Alcohol Clin Exp Res
  2. Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats.
    Authors: Kemp Et al.
    PLoS Comput Biol
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