[D-Lys3]-GHRP-6

  ( 5 citations )    
Product Datasheet
Catalog Number:1922
Chemical Name:
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
Technical Data
  • M.Wt:
    930.12
  • Formula:
    C49H63N13O6
  • Sequence:
    HWKWFK

    (Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)

  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    136054-22-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:

5 Citations: Showing 1 - 5
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  1. Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.
    Authors: Kamei Et al.
    PLoS One  2017;12:e0171819
  2. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  3. The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice.
    Authors: Gomez and
    Alcohol Clin Exp Res  2014;38:2436
  4. Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion.
    Authors: Song Et al.
    PLoS One  2013;8:e65422
  5. Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats.
    Authors: Kemp Et al.
    PLoS Comput Biol  2011;57:633

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human GHSR (NP_940799) VersaClone cDNA

RDC0404
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