Antagonist at the ghrelin receptor (GHS-R1a) (IC50
= 0.9 μ
M). Also weakly binds to melanocortin receptors (Ki
= 26-120 μ
M). Centrally active in vivo
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Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes.
Schioth et al.
Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus.
Traebert et al.
Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids.
Pinilla et al.
The citations listed below are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:
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