Catalog Number: 3054
Biological Activity
Selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6,Leu17]VIP.
    Pandol et al.
    Am.J.Physiol., 1986;250:G553
  2. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages.
    Pozo et al.
    Eur.J.Pharmacol., 1997;321:379
  3. Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells.
    Xie et al.
    Mol.Pharmacol., 2007;72:73

The citations listed below are publications that use Tocris products. Selected citations for [D-p-Cl-Phe6,Leu17]-VIP include:

Showing Results 1 - 4 of 4

  1. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
    Authors: Maugeri Et al.
    Sci Rep
  2. Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
    Authors: Jones Et al.
    Nat Neurosci
  3. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
    Authors: Nedvetsky Et al.
    Dev Cell
  4. Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons.
    Authors: Evans Et al.
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