[D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Name: [D-p-Cl-Phe 6 ,Leu 17 ]-VIP
Brand: Tocris Bioscience
SKU: 3054
Price: 399 USD
Availability: InStock

Tocris Bioscience | Catalog # 3054

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Citations (13)

Product Documents

Selective VIP receptor antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective VIP receptor antagonist

View all VIP Receptor Antagonists »

Product Description

[D-p-Cl-Phe⁶,Leu¹⁷]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC₅₀ = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

Product Specifications for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Molecular Weight

3342.24

Formula

C₁₄₈H₂₃₉ClN₄₄O₄₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

102805-45-8

PubChem ID

90488798

InChI Key

BUTRVBZATBJGPP-BERWWWERSA-N

SMILES

[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Pozo Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur.J.Pharmacol. 1997 PMID: 9085051
Xie Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol.Pharmacol. 2007 PMID: 17430995
Pandol Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe⁶,Leu¹⁷]VIP. Am.J.Physiol. 1986 PMID: 2421587

Product Documents for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

For research use only

Citations for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

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