Biological Activity[D-p-Cl-Phe6,Leu17]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.
(Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6,Leu17]VIP.
Pandol et al.
Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages.
Pozo et al.
Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells.
Xie et al.
Citations for [D-p-Cl-Phe6,Leu17]-VIP
The citations listed below are publications that use Tocris products. Selected citations for [D-p-Cl-Phe6,Leu17]-VIP include:
4 Citations: Showing 1 - 4
PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
Authors: Maugeri Et al.
Sci Rep 2016;7:139
Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
Authors: Jones Et al.
Nat Neurosci 2015;18:373
Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
Authors: Nedvetsky Et al.
Dev Cell 2014;30:449
Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons.
Authors: Evans Et al.
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