Catalog Number: 3054
Biological Activity
Selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.
Technical Data
  • M.Wt:
    3342.24
  • Formula:
    C148H239ClN44O42
  • Sequence:
    HSDAVFTDNYTRLRKQLAVKKYLNSILN

    (Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    102805-45-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6,Leu17]VIP.
    Pandol et al.
    Am.J.Physiol., 1986;250:G553
  2. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages.
    Pozo et al.
    Eur.J.Pharmacol., 1997;321:379
  3. Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells.
    Xie et al.
    Mol.Pharmacol., 2007;72:73
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [D-p-Cl-Phe6,Leu17]-VIP include:

4 Citations: Showing 1 - 4
Filter your results:

  1. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
    Authors: Maugeri Et al.
    Sci Rep 2016;7:139
  2. Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
    Authors: Jones Et al.
    Nat Neurosci 2015;18:373
  3. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
    Authors: Nedvetsky Et al.
    Dev Cell 2014;30:449
  4. Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons.
    Authors: Evans Et al.
    Neuron 2013;80:973

Have you used [D-p-Cl-Phe6,Leu17]-VIP?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information