Dantrolene, sodium salt

Tocris Bioscience | Catalog # 0507

Ca2+ release inhibitor
Tocris Bioscience

Key Product Details

Description

Ca2+ release inhibitor
View all Ryanodine Receptor Inhibitors »

Product Description

Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

Product Specifications for Dantrolene, sodium salt

Molecular Weight

336.23

Formula

C14H9N4NaO5

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt

CAS Number

14663-23-1

PubChem ID

6604100

InChI Key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

SMILES

O=C([N-]3)N(CC3=O)/N=C/C1=CC=C(C2=CC=C([N+]([O-])=O)C=C2)O1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.36 10

Preparing Stock Solutions for Dantrolene, sodium salt

The following data is based on the product molecular weight 336.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.74 mL 148.71 mL 297.42 mL
0.5 mM 5.95 mL 29.74 mL 59.48 mL
1 mM 2.97 mL 14.87 mL 29.74 mL
5 mM 0.59 mL 2.97 mL 5.95 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for Dantrolene, sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Dantrolene, sodium salt

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Dantrolene, sodium salt

Customer Reviews for Dantrolene, sodium salt (1)

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  • Dantrolene modulates synaptic function
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 08/17/2019
    Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.
    Dantrolene, sodium salt 0507

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