Dantrolene, sodium salt

Catalog # Availability Size / Price Qty
0507/100
Dantrolene, sodium salt | CAS No. 14663-23-1 | Ryanodine Receptor Inhibitors
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Description: Ca2+ release inhibitor

Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt

Purity: ≥98%

Product Details
Citations (9)
Reviews (1)

Biological Activity

Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

Technical Data

M.Wt:
336.23
Formula:
C14H9N4NaO5
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
14663-23-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Dantrolene, sodium salt

The citations listed below are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:

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Dantrolene modulates synaptic function
By Anonymous on 08/17/2019
Application: Species: Rat

Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.


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