Dantrolene, sodium salt

  ( 4 citations )    
Product Datasheet
Catalog Number:0507
Chemical Name:1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Product Details
Citations (4)
Reviews
Biological Activity
Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
Technical Data
  • M.Wt:
    336.23
  • Formula:
    C14H9N4NaO5
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    14663-23-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:

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  1. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
    Authors: Efthymiou Et al.
    Int J Mol Sci  2015;4:230
  2. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    FEMS Immunol Med Microbiol  2015;16:5555
  3. Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo.
    Authors: Drdla and Sandkühler
    Mol Pain  2008;4:18
  4. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Pharmacol Exp Ther  2006;47:296

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