Inhibits release of Ca2+
from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
Soluble to 10 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
Hotchkiss and Karl
Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus.
O'Mara et al.
Dantrolene inhibition of ryanodine receptor Ca2+ release channels.
Zhao et al.
The citations listed below are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:
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