Catalog Number: 0507
Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Biological Activity
Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
Technical Data
  • M.Wt:
    336.23
  • Formula:
    C14H9N4NaO5
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    14663-23-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
    Hotchkiss and Karl
    Proc.Natl.Acad.Sci.U.S.A., 1994;91:3039
  3. Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus.
    O'Mara et al.
    Neuroscience, 1995;68:621
  4. Dantrolene inhibition of ryanodine receptor Ca2+ release channels.
    Zhao et al.
    J.Biol.Chem., 2001;276:13810
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:

3 Citations: Showing 1 - 3
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  1. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
    Authors: Efthymiou Et al.
    Int J Mol Sci 2015;4:230
  2. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    FEMS Immunol Med Microbiol 2015;16:5555
  3. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Pharmacol Exp Ther 2006;47:296

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