Dantrolene, sodium salt
Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Biological ActivityInhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
Hotchkiss and Karl
Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus.
O'Mara et al.
Dantrolene inhibition of ryanodine receptor Ca2+ release channels.
Zhao et al.
Citations for Dantrolene, sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:
9 Citations: Showing 1 - 9
High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Authors: Florea Et al.
Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
Authors: Efthymiou Et al.
Int J Mol Sci 2015;4:230
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Authors: Lin Et al.
FEMS Immunol Med Microbiol 2015;16:5555
Role of Na+/Ca2+ exchanger in Ca2+ homeostasis in rat suprachiasmatic nucleus neurons.
Authors: Wang Et al.
J Neurophysiol 2015;113:2114
Mobilization of calcium from intracellular stores facilitates somatodendritic DA release.
Authors: Patel Et al.
J Neurosci 2009;29:6568
Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo.
Authors: Drdla and Sandkühler
Mol Pain 2008;4:18
Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
Authors: Wieland Et al.
J Pharmacol Exp Ther 2006;47:296
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Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.