Darapladib

Key Product Details

Product Description

Darapladib is a potent lipoprotein-associated phospholipase A₂ (lp-PLA₂) inhibitor (IC₅₀ = 5 nM in whole human plasma).

Product Specifications for Darapladib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Darapladib

The following data is based on the product molecular weight 666.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.50 mL	7.50 mL	15.00 mL
5 mM	0.30 mL	1.50 mL	3.00 mL
10 mM	0.15 mL	0.75 mL	1.50 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Blackie The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A₂. Bioorg.Med.Chem.Lett. 2003 PMID: 12643913

Product Documents for Darapladib