Chemical Name: (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
Biological ActivityDaunorubicin hydrochloride is a DNA topoisomerase II inhibitor. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.Anticancer agent. Exhibits activity against nonlymphocytic leukemia. Identified as targeting human host proteins that interact with SARS-CoV-2. Also enhances adeno-associated virus transduction of HeLa cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review.
Aubel-Sadron and Londos-Gagliardi
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
Dickey et al.
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunoru.
Signaling pathways activated by daunoru.
Laurent and Jaffrezou
Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens.
Nicolson et al.
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.
Pommier et al.
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
Citations for Daunorubicin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Daunorubicin hydrochloride include:
3 Citations: Showing 1 - 3
Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes.
Authors: Zhao and Zhang
Sci Rep 2017;7:44735
Oxidized porous silicon particles covalently grafted with daunoru. as a sustained intraocular drug delivery system.
Authors: Chhablani Et al.
Invest Ophthalmol Vis Sci 2013;54:1268
An alternative direct compound dispensing method using the HP D300 digital dispenser.
Authors: Jones Et al.
PLoS One 2013;18:367
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Mechanism of action of Daunorubicin hydrochloride was studied in order to understand the inhibition of the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription.