Daunorubicin hydrochloride

Tocris Bioscience | Catalog # 1467

DNA topoisomerase II inhibitor
Tocris Bioscience

Key Product Details

Description

DNA topoisomerase II inhibitor

Alternative Names

Daunomycin
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Product Description

Daunorubicin hydrochloride is a DNA topoisomerase II inhibitor. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.Anticancer agent. Exhibits activity against nonlymphocytic leukemia. Identified as targeting human host proteins that interact with SARS-CoV-2. Also enhances adeno-associated virus transduction of HeLa cells in vitro.

Product Specifications for Daunorubicin hydrochloride

Molecular Weight

563.99

Formula

C27H29NO10.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride

CAS Number

23541-50-6

PubChem ID

3085106

InChI Key

GUGHGUXZJWAIAS-CFCXLQPVSA-N

SMILES

NC1CC(O[C@H]2C[C@@]([C@@](C)=O)(O)CC3=C2C(O)=C5C(C(C4=CC=CC(OC)=C4C5=O)=O)=C3O)OC(C)C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50

Preparing Stock Solutions for Daunorubicin hydrochloride

The following data is based on the product molecular weight 563.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.55 mL 17.73 mL 35.46 mL
2.5 mM 0.71 mL 3.55 mL 7.09 mL
5 mM 0.35 mL 1.77 mL 3.55 mL
25 mM 0.07 mL 0.35 mL 0.71 mL

Calculators

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Product Documents for Daunorubicin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Daunorubicin hydrochloride

For research use only

⚠ WARNING: This product can expose you to chemicals including Daunorubicin hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Daunorubicin hydrochloride

Customer Reviews for Daunorubicin hydrochloride (1)

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  • Mechanism of action of Daunorubicin hydrochloride was studied
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/26/2019
    Mechanism of action of Daunorubicin hydrochloride was studied in order to understand the inhibition of the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription.
    Daunorubicin hydrochloride 1467

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