Catalog Number: 1467
Alternate Names: Daunomycin
Chemical Name: (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
Biological Activity
Anticancer agent that is clinically used to treat nonlymphocytic leukemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.
Technical Data
  • M.Wt:
    563.99
  • Formula:
    C27H29NO10.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    23541-50-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
    Gewirtz
    Biochem.Pharmacol., 1999;57:727
  2. Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review.
    Aubel-Sadron and Londos-Gagliardi
    Biochimie, 1984;66:333
  3. Signaling pathways activated by daunorubicin.
    Laurent and Jaffrezou
    Blood, 2001;98:913
  4. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
    Dickey et al.
    Mol.Neurodegen., 2006;1:6
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Daunorubicin hydrochloride include:

1 Citations: Showing 1 - 1

  1. An alternative direct compound dispensing method using the HP D300 digital dispenser.
    Authors: Jones Et al.
    PLoS One 2013;18:367

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