Davunetide

Tocris Bioscience | Catalog # 6779

Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
Tocris Bioscience

Key Product Details

Description

Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo

Alternative Names

AL-108,NAP (peptide),NAPVSIPQ
View all Amyloid beta Peptide Inhibitors »

Product Description

Davunetide is a highly potent active component of activity-dependent neuroprotective protein (ADNP). Prevents β-amyloid aggregation. Reduces hyperphosphorylated tau levels and increases tau-microtubule interactions; neuroprotective at femtomolar concentrations in vitro. Exerts neuroprotective effects in schizophrenia models associated with microtubule-autophagy insufficiency in MAP6-deficient mice. Modulates HIFs and VEGF expression and suppresses retinal cell apoptosis in an in vivo diabetic retinopathy model.

Product Specifications for Davunetide

Molecular Weight

824.93

Formula

C36H60N10O12

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

211439-12-2

PubChem ID

9832404

InChI Key

DWLTUUXCVGVRAV-XWRHUKJGSA-N

SMILES

O=C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Product Documents for Davunetide

Certificate of Analysis

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Product Specific Notices for Davunetide

For research use only

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