Catalog Number: 5357
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Biological Activity
Free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats.
    Zhang et al.
    Biomed.Pharmacother., 2010;64:647
  2. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice.
    Sun et al.
    PLoS ONE, 2013;8:e66744
  3. A novel class of antagonists for the FFAs receptor GPR40.
    Hu et al.
    Biochem.Biophys.Res.Comm., 2009;390:557
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