Catalog Number: 2755
Chemical Name: Sodium dichloroacetate
Biological Activity
Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.
Technical Data
  • M.Wt:
    150.92
  • Formula:
    C2HCl2NaO2
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    2156-56-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.
    Bowker-kinley et al.
    Biochem.J., 1998;329:191
  2. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
    Bonnet et al.
    Cancer Cell, 2007;11:37
  3. The pharmacology of dichloroacetate.
    Stacpoole
    Metabolism Clin.Exp., 1989;38:1124
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