Chemical Name: Sodium dichloroacetate
Biological ActivityDCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.
Bowker-kinley et al.
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Bonnet et al.
Cancer Cell, 2007;11:37
The pharmacology of dichloroacetate.
Metabolism Clin.Exp., 1989;38:1124
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