DCA

Tocris Bioscience | Catalog # 2755

Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
Tocris Bioscience

Key Product Details

Description

Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
View all Other Kinase Inhibitors »

Product Description

DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

Product Specifications for DCA

Molecular Weight

150.92

Formula

C2HCl2NaO2

Storage

Desiccate at RT

Chemical Name

Sodium dichloroacetate

CAS Number

2156-56-1

PubChem ID

517326

InChI Key

LUPNKHXLFSSUGS-UHFFFAOYSA-M

SMILES

[Na+].[O-]C(=O)C(Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.09 100
DMSO 15.09 100

Preparing Stock Solutions for DCA

The following data is based on the product molecular weight 150.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.63 mL 33.13 mL 66.26 mL
5 mM 1.33 mL 6.63 mL 13.25 mL
10 mM 0.66 mL 3.31 mL 6.63 mL
50 mM 0.13 mL 0.66 mL 1.33 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for DCA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DCA

For research use only

Customer Reviews for DCA (1)

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  • DCA assay
    Name: Xiaoyu Zhang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: 293T
    Verified Customer | Posted 03/08/2024
    20mM treatment of 293T cells for 24hours. Western blot detects p53 expression after DCA treatment.
    DCA 2755

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