Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Biological ActivityStimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
DCEBIO stimulates Cl- secretion in the mouse jejunum.
Hamilton and Kiessling et al.
Am.J.Physiol.Cell Physiol., 2006;290:152
Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
Singh et al.
Citations for DCEBIO
The citations listed below are publications that use Tocris products. Selected citations for DCEBIO include:
5 Citations: Showing 1 - 5
Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
Authors: McCully Et al.
J Immunol 2015;195:96
Benzimidazolones enhance the function of epithelial Na+ transport.
Authors: Laube Et al.
Br J Pharmacol 2013;168:1329
Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener.
Authors: Hirota and McKay
Br J Pharmacol 2009;156:1085
Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.
Authors: MacVinish Et al.
J Reprod Dev 2007;150:1055
Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis.
Authors: Fioretti Et al.
Am J Physiol Cell Physiol 2005;289:C89
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