Catalog Number: 1422
Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Biological Activity
Stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).
Technical Data
  • M.Wt:
    231.08
  • Formula:
    C9H8Cl2N2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    60563-36-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. DCEBIO stimulates Cl- secretion in the mouse jejunum.
    Hamilton and Kiessling et al.
    Am.J.Physiol.Cell Physiol., 2006;290:152
  2. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
    Singh et al.
    J.Pharmacol.Exp.Ther., 2001;296:600
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DCEBIO include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
    Authors: McCully Et al.
    J Immunol 2015;195:96
  2. Benzimidazolones enhance the function of epithelial Na+ transport.
    Authors: Laube Et al.
    Br J Pharmacol 2013;168:1329
  3. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.
    Authors: MacVinish Et al.
    J Reprod Dev 2007;150:1055

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