DCEBIO

Catalog # Availability Size / Price Qty
1422/10
1422/50
CFTR Activators Small Molecule
1 Image
Description: Activates Cl- conductance and hKCa3.1 channels

Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

Stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Technical Data

M.Wt:
231.08
Formula:
C9H8Cl2N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
60563-36-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. DCEBIO stimulates Cl- secretion in the mouse jejunum.
    Hamilton and Kiessling et al.
    Am.J.Physiol.Cell Physiol., 2006;290:152
  2. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
    Singh et al.
    J.Pharmacol.Exp.Ther., 2001;296:600

Product Datasheets

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Citations for DCEBIO

The citations listed below are publications that use Tocris products. Selected citations for DCEBIO include:

5 Citations: Showing 1 - 5

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