Chemical Name: 1-Ethyl-2-benzimidazolinone
Biological ActivityActivator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
Kleger et al.
1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels.
Ayotunde and Adeagbo
Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+ - dependent K+ channel.
Devor et al.
Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration.
Kusama et al.
Citations for 1-EBIO
The citations listed below are publications that use Tocris products. Selected citations for 1-EBIO include:
16 Citations: Showing 1 - 10
Targeting potassium channels to treat cerebellar ataxia.
Authors: Bushart Et al.
Ann Clin Transl Neurol 2018;5:297
Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice.
Authors: Wells Et al.
Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.
Authors: Gamble-George Et al.
Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.
Authors: Rau Et al.
BMC Dermatol 2015;35:9730
Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
Authors: Cuppoletti Et al.
Am J Physiol Cell Physiol 2014;307:C479
Methadone but not mor. inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Authors: Cuppoletti Et al.
Cell Biochem Biophys 2013;66:53
Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells.
Authors: Choi Et al.
Eur J Immunol 2013;17:181
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Authors: Benton Et al.
J Neurophysiol 2013;109:2528
Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease.
Authors: Park Et al.
Cardiovasc Res 2011;89:290
Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.
Authors: Haddock Et al.
PLoS One 2011;6:e16423
PRL-3 promotes the proliferation of LoVo cells via the upregulation of KCNN4 channels.
Authors: Lai Et al.
Oncol Rep 2011;26:909
Functional KCa3.1 K+ channels are required for human fibrocyte migration.
Authors: Cruse Et al.
J Allergy Clin Immunol 2011;128:1303
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
Authors: Duffy Et al.
Proc Natl Acad Sci U S A 2007;37:1653
Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration.
Authors: Kusama Et al.
Br J Pharmacol 2005;146:487
Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed.
Authors: Manaves Et al.
Korean J Physiol Pharmacol 2004;4:7
New insights on the voltage dependence of the KCa3.1 channel block by internal TBA.
Authors: Banderali Et al.
J Gen Physiol 2004;124:333
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Reviews for 1-EBIO
Average Rating: 5 (Based on 1 Review)
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It activates Ca2+ activated K+ channels on epithelium. Our University lab uses it to study Big Conductance Channel channel opening.