1-EBIO

Catalog # Availability Size / Price Qty
1041/10
1041/50
1-EBIO | CAS No. 10045-45-1 | Ca2+-Activated Potassium Channel Activators
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Description: Activator of epithelial KCa channels

Chemical Name: 1-Ethyl-2-benzimidazolinone

Purity: ≥99%

Product Details
Citations (16)
Reviews (1)

Biological Activity

Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

Technical Data

M.Wt:
162.19
Formula:
C9H10N2O
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
10045-45-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 1-EBIO

The citations listed below are publications that use Tocris products. Selected citations for 1-EBIO include:

16 Citations: Showing 1 - 10

  1. Targeting potassium channels to treat cerebellar ataxia.
    Authors: Bushart Et al.
    Ann Clin Transl Neurol  2018;5:297
  2. Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice.
    Authors: Wells Et al.
    Nature  2016;532:58
  3. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.
    Authors: Gamble-George Et al.
    Elife  2016;5
  4. Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.
    Authors: Rau Et al.
    BMC Dermatol  2015;35:9730
  5. Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
    Authors: Cuppoletti Et al.
    Am J Physiol Cell Physiol  2014;307:C479
  6. Methadone but not mor. inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
    Authors: Cuppoletti Et al.
    Cell Biochem Biophys  2013;66:53
  7. Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells.
    Authors: Choi Et al.
    Eur J Immunol  2013;17:181
  8. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol  2013;109:2528
  9. Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease.
    Authors: Park Et al.
    Cardiovasc Res  2011;89:290
  10. Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.
    Authors: Haddock Et al.
    PLoS One  2011;6:e16423

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Study on BK channel activity
By Eleanor Baxter on 10/23/2018
Species: Human

It activates Ca2+ activated K+ channels on epithelium. Our University lab uses it to study Big Conductance Channel channel opening.


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