Catalog Number: 1041
Chemical Name: 1-Ethyl-2-benzimidazolinone
Biological Activity
Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
Technical Data
  • M.Wt:
    162.19
  • Formula:
    C9H10N2O
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    10045-45-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels.
    Ayotunde and Adeagbo
    Eur.J.Pharmacol., 1999;379:151
  2. Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+ - dependent K+ channel.
    Devor et al.
    Am.J.Physiol., 1996;271:L775
  3. Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration.
    Kusama et al.
    Br.J.Pharmacol., 2005;146:487
  4. Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
    Kleger et al.
    Circulation., 2010;122:1823

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