( 14 citations )    
Product Datasheet
Catalog Number:1041
Chemical Name:1-Ethyl-2-benzimidazolinone
Product Details
Citations (14)
Biological Activity
Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for 1-EBIO include:

14 Citations: Showing 1 - 10
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  1. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.
    Authors: Gamble-George Et al.
    Elife  2016;5
  2. Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.
    Authors: Rau Et al.
    BMC Dermatol  2015;35:9730
  3. Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
    Authors: Cuppoletti Et al.
    Am J Physiol Cell Physiol  2014;307:C479
  4. Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
    Authors: Cuppoletti Et al.
    Cell Biochem Biophys  2013;66:53
  5. Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells.
    Authors: Choi Et al.
    Eur J Immunol  2013;17:181
  6. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol  2013;109:2528
  7. Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease.
    Authors: Park Et al.
    Cardiovasc Res  2011;89:290
  8. Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.
    Authors: Haddock Et al.
    PLoS One  2011;6:e16423
  9. PRL-3 promotes the proliferation of LoVo cells via the upregulation of KCNN4 channels.
    Authors: Lai Et al.
    Oncol Rep  2011;26:909
  10. Functional KCa3.1 K+ channels are required for human fibrocyte migration.
    Authors: Cruse Et al.
    J Allergy Clin Immunol  2011;128:1303
  11. Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
    Authors: Duffy Et al.
    Proc Natl Acad Sci U S A  2007;37:1653
  12. Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration.
    Authors: Kusama Et al.
    Br J Pharmacol  2005;146:487
  13. Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed.
    Authors: Manaves Et al.
    Korean J Physiol Pharmacol  2004;4:7
  14. New insights on the voltage dependence of the KCa3.1 channel block by internal TBA.
    Authors: Banderali Et al.
    J Gen Physiol  2004;124:333
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