dCeMM2

Key Product Details

Product Description

dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.

Product Specifications for dCeMM2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for dCeMM2

The following data is based on the product molecular weight 370.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.39 mL	26.97 mL	53.93 mL
2.5 mM	1.08 mL	5.39 mL	10.79 mL
5 mM	0.54 mL	2.70 mL	5.39 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mayor-Ruiz Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 2020 PMID: 32747809

Product Documents for dCeMM2