Chemical Name: 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
Biological ActivityVolume-regulated anion channel (VRAC) blocker (IC50 ~ 2 μM in rat pancreatic β-cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 μM, in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents.
Best et al.
Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative.
Bourke et al.
DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration.
Decher et al.
DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels.
Lv et al.
Citations for DCPIB
The citations listed below are publications that use Tocris products. Selected citations for DCPIB include:
15 Citations: Showing 1 - 10
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Authors: Woo Et al.
Exp Neurobiol 2019;28:30
Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain.
Authors: Han Et al.
Exp Neurobiol 2019;28:183
Swelling-induced chloride current in glioblastoma proliferation, migration, and invasion.
Authors: Wong Et al.
J Cell Physiol 2018;233:363
Leucine-rich repeat-containing 8B protein is associated with the endoplasmic reticulum Ca2+ leak in HEK293 cells.
Authors: Ghosh Et al.
J Cell Sci 2017;130:3818
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
Authors: Draganov Et al.
J Cell Sci 2015;5:16222
A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
Authors: Catalán Et al.
Int J Clin Exp Med 2015;112:2263
Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes.
Authors: Takada Et al.
Dig Dis Sci 2014;127:4159
Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes.
Authors: Sabirov Et al.
PLoS One 2013;8:e55646
Electrophysiological characteristics of enteric neurons isolated from the immortomouse.
Authors: Hawkins Et al.
Proc Natl Acad Sci U S A 2013;58:1516
Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.
Authors: Li Et al.
J Cell Physiol 2012;227:172
Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.
Authors: Hyzinski-García Et al.
J Neurochem 2011;118:140
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Authors: Raucci Et al.
Cardiovasc Res 2010;86:55
Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release.
Authors: Schlichter Et al.
Channels (Austin) 2010;5:128
Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons.
Authors: Li and Olson
Am J Physiol Cell Physiol 2008;295:C1550
DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra.
Authors: Zhang Et al.
Exp Neurol 2008;210:514
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DCPIB is a volume regulated anion channel. We used at 20-30microM in rat brain slice.