DCPIB

  ( 10 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1540
Chemical Name:4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
Product Details
Citations (10)
Reviews
Biological Activity
Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC50 ~ 2 μM) and ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl- and K+ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.
Technical Data
  • M.Wt:
    427.37
  • Formula:
    C22H28Cl2O4
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    82749-70-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DCPIB include:

10 Citations: Showing 1 - 10
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  1. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    J Cell Sci  2015;5:16222
  2. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
    Authors: Catal&#225;n Et al.
    Int J Clin Exp Med  2015;112:2263
  3. Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes.
    Authors: Takada Et al.
    Dig Dis Sci  2014;127:4159
  4. Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes.
    Authors: Sabirov Et al.
    PLoS One  2013;8:e55646
  5. Electrophysiological characteristics of enteric neurons isolated from the immortomouse.
    Authors: Hawkins Et al.
    Proc Natl Acad Sci U S A  2013;58:1516
  6. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.
    Authors: Li Et al.
    J Cell Physiol  2012;227:172
  7. Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.
    Authors: Hyzinski-Garc&#237;a Et al.
    J Neurochem  2011;118:140
  8. Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release.
    Authors: Schlichter Et al.
    Channels (Austin)  2010;5:128
  9. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons.
    Authors: Li and Olson
    Am J Physiol Cell Physiol  2008;295:C1550
  10. DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra.
    Authors: Zhang Et al.
    Exp Neurol  2008;210:514

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Average Rating: 4 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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