Catalog Number: 1540
Chemical Name: 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
Biological Activity
Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC50 ~ 2 μM) and ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl- and K+ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative.
    Bourke et al.
    J.Neurosurg., 1981;55:364
  2. DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration.
    Decher et al.
    Br.J.Pharmacol., 2001;134:1467
  3. Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents.
    Best et al.
    Eur.J.Pharmacol., 2004;489:13
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