DCPIB

Catalog # Availability Size / Price Qty
1540/10
1540/50
DCPIB | CAS No. 82749-70-0 | Other Chloride Channel Blockers
1 Image
Description: Blocker of VRAC/ICl, swell

Chemical Name: 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid

Purity: ≥98%

Product Details
Citations (15)
Reviews (1)

Biological Activity

Volume-regulated anion channel (VRAC) blocker (IC50 ~ 2 μM in rat pancreatic β-cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 μM, in vitro.

Technical Data

M.Wt:
427.37
Formula:
C22H28Cl2O4
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
82749-70-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DCPIB

The citations listed below are publications that use Tocris products. Selected citations for DCPIB include:

15 Citations: Showing 1 - 10

  1. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
    Authors: Woo Et al.
    Exp Neurobiol  2019;28:30
  2. Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain.
    Authors: Han Et al.
    Exp Neurobiol  2019;28:183
  3. Swelling-induced chloride current in glioblastoma proliferation, migration, and invasion.
    Authors: Wong Et al.
    J Cell Physiol  2018;233:363
  4. Leucine-rich repeat-containing 8B protein is associated with the endoplasmic reticulum Ca2+ leak in HEK293 cells.
    Authors: Ghosh Et al.
    J Cell Sci  2017;130:3818
  5. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    J Cell Sci  2015;5:16222
  6. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
    Authors: Catalán Et al.
    Int J Clin Exp Med  2015;112:2263
  7. Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes.
    Authors: Takada Et al.
    Dig Dis Sci  2014;127:4159
  8. Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes.
    Authors: Sabirov Et al.
    PLoS One  2013;8:e55646
  9. Electrophysiological characteristics of enteric neurons isolated from the immortomouse.
    Authors: Hawkins Et al.
    Proc Natl Acad Sci U S A  2013;58:1516
  10. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.
    Authors: Li Et al.
    J Cell Physiol  2012;227:172

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a VRACs blocker
By Anonymous on 02/02/2018
Application: Species: Rat

DCPIB is a volume regulated anion channel. We used at 20-30microM in rat brain slice.


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