DCPIB (CAS 82749-70-0): R&D Systems
Catalog Number: 1540
Chemical Name: 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
Biological Activity
Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC50 ~ 2 μM) and ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl- and K+ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative.
    Bourke et al.
    J.Neurosurg., 1981;55:364
  2. DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration.
    Decher et al.
    Br.J.Pharmacol., 2001;134:1467
  3. Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents.
    Best et al.
    Eur.J.Pharmacol., 2004;489:13

The citations listed below are publications that use Tocris products. Selected citations for DCPIB include:

7 Citations: Showing 1 - 7
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  1. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    J Cell Sci 2015;5:16222
  2. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
    Authors: Catal&#225;n Et al.
    Int J Clin Exp Med 2015;112:2263
  3. Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes.
    Authors: Takada Et al.
    Dig Dis Sci 2014;127:4159
  4. Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes.
    Authors: Sabirov Et al.
    PLoS One 2013;8:e55646
  5. Electrophysiological characteristics of enteric neurons isolated from the immortomouse.
    Authors: Hawkins Et al.
    Proc Natl Acad Sci U S A 2013;58:1516
  6. Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.
    Authors: Hyzinski-Garc&#237;a Et al.
    J Neurochem 2011;118:140
  7. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons.
    Authors: Li and Olson
    Am J Physiol Cell Physiol 2008;295:C1550

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