Biological ActivitySubtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Also inhibits cleavage of SARS-CoV-2 spike protein by furin.
(Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.
Garcia et al.
Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors.
Tian and Jianhua
Inhibition of convertase-related processing of proendothelin-1.
Denault et al.
Citations for Decanoyl-RVKR-CMK
The citations listed below are publications that use Tocris products. Selected citations for Decanoyl-RVKR-CMK include:
5 Citations: Showing 1 - 5
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.
Authors: Hoffman Et al.
Mol Cell 2020;78:779
Biowire Model of Interstitial and Focal Cardiac Fibrosis.
Authors: Wang Et al.
ACS Cent Sci 2019;5:1146
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells.
Authors: Matsuyama Et al.
J Virol 2018;92
The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation.
Am J Physiol Gastrointest Liver Physiol 2014;55:1066
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein.
Authors: Millet & Whittaker
Proc Natl Acad Sci U S A 2014;111:15214
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