Catalog Number: 3501
Biological Activity
Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
Technical Data
  • M.Wt:
    744.42
  • Formula:
    C34H66ClN11O5
  • Sequence:
    RVKR

    (Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    150113-99-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.
    Garcia et al.
    J.Biol.Chem., 2005;280:41595
  2. Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors.
    Tian and Jianhua
    Int.J.Biol.Sci., 2010;6:89
  3. Inhibition of convertase-related processing of proendothelin-1.
    Denault et al.
    J.Cardiovasc.Pharmacol., 1995;26:S47
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Decanoyl-RVKR-CMK include:

1 Citations: Showing 1 - 1

  1. The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation.
    Authors: Edin
    Am J Physiol Gastrointest Liver Physiol 2014;55:1066

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