Home / Furin Inhibitors / Decanoyl-RVKR-CMK

Decanoyl-RVKR-CMK

Catalog #: 3501
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3501/1
Decanoyl-RVKR-CMK
1 Image
Description: Subtilisin/Kex2p-like proprotein convertase inhibitor

Purity: ≥95%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).

Technical Data

M.Wt:
744.42
Formula:
C34H66ClN11O5
Sequence:
RVKR

(Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
150113-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Decanoyl-RVKR-CMK

The citations listed below are publications that use Tocris products. Selected citations for Decanoyl-RVKR-CMK include:

6 Citations: Showing 1 - 6

  1. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.
    Authors: Hoffman Et al.
    Mol Cell  2020;78:779
  2. Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
    Authors: Cheng Et al.
    Cell Rep.  2020;33:108254
  3. Biowire Model of Interstitial and Focal Cardiac Fibrosis.
    Authors: Wang Et al.
    ACS Cent Sci  2019;5:1146
  4. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells.
    Authors: Matsuyama Et al.
    J Virol  2018;92
  5. The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation.
    Authors: Edin
    Am J Physiol Gastrointest Liver Physiol  2014;55:1066
  6. Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein.
    Authors: Millet & Whittaker
    Proc Natl Acad Sci U S A  2014;111:15214

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