Decanoyl-RVKR-CMK

Catalog # Availability Size / Price Qty
3501/1
Decanoyl-RVKR-CMK
1 Image
Description: Subtilisin/Kex2p-like proprotein convertase inhibitor

Purity: ≥95%

Product Details
Citations (13)
Reviews

Biological Activity

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).

Technical Data

M.Wt:
744.42
Formula:
C34H66ClN11O5
Sequence:
RVKR

(Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
150113-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Decanoyl-RVKR-CMK

The citations listed below are publications that use Tocris products. Selected citations for Decanoyl-RVKR-CMK include:

13 Citations: Showing 1 - 10

  1. A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry.
    Authors: Wei Et al.
    Cell  2023;186:850-863.e16
  2. High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler.
    Authors: Jurga Et al.
    Nat Biotechnol  2023;
  3. A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants.
    Authors: Robert W Et al.
    Viruses  2022;14
  4. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung.
    Authors: Dong Et al.
    Nat Commun  2021;12:134
  5. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation.
    Authors: Robert F Et al.
    Elife  2021;10
  6. The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans.
    Authors: Henrik Et al.
    Elife  2020;9
  7. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.
    Authors: Hoffman Et al.
    Mol Cell  2020;78:779
  8. Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
    Authors: Cheng Et al.
    Cell Rep.  2020;33:108254
  9. Biowire Model of Interstitial and Focal Cardiac Fibrosis.
    Authors: Wang Et al.
    ACS Cent Sci  2019;5:1146
  10. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells.
    Authors: Matsuyama Et al.
    J Virol  2018;92

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