Decanoyl-RVKR-CMK

Name: Decanoyl-RVKR-CMK
Brand: Tocris Bioscience
SKU: 3501
Price: 257 USD
Availability: InStock

Tocris Bioscience | Catalog # 3501

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Citations (28)

Product Documents

Subtilisin/Kex2p-like proprotein convertase inhibitor

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Subtilisin/Kex2p-like proprotein convertase inhibitor

View all Furin Inhibitors »

Product Description

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC₅₀ = 57 nM in plaque reduction assay).

Product Specifications for Decanoyl-RVKR-CMK

Molecular Weight

744.42

Formula

C₃₄H₆₆ClN₁₁O₅

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

150113-99-8

PubChem ID

9962075

InChI Key

NHBJTTGFHCHQHS-VZTVMPNDSA-N

SMILES

[H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Vey Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediatedby the human endoprotease furin. Virology 1995 PMID: 7726996
Cheng Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 2020 PMID: 33007239
Tian and Jianhua Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int.J.Biol.Sci. 2010 PMID: 20151049
Denault Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 1995 PMID: 8587448
Garcia A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 2005 PMID: 16221685

Product Documents for Decanoyl-RVKR-CMK

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Decanoyl-RVKR-CMK

For research use only

Related Research Areas

Notch Pathway

Serine Proteases and Regulators

Citations for Decanoyl-RVKR-CMK

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