Catalog Number: 1819
Alternate Names: DAQ B1, L-783,281, DMAQ-B1
Chemical Name: 2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
Biological Activity
Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.
    Kim et al.
    J.Med.Chem., 2007;50:3423
  2. A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells.
    Weber et al.
    J.Vasc.Surg., 2000;32:1118
  3. Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator.
    Webster et al.
    Chembiochem, 2003;4:379
  4. Discovery of a small molecule insulin receptor activator.
    Salituro et al.
    Recent Prog.Horm.Res., 2001;56:107
  5. The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors.
    Wilkie et al.
    J.Neurochem., 2001;78:1135
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