Demethylasterriquinone B1

Catalog # Availability Size / Price Qty
1819/5
Demethylasterriquinone B1 | CAS No. 78860-34-1 | Insulin and Insulin-like Receptor Activators
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Description: Selective insulin RTK activator
Alternative Names: DAQ B1, L-783,281, DMAQ-B1

Chemical Name: 2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Technical Data

M.Wt:
506.59
Formula:
C32H30N2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
78860-34-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Demethylasterriquinone B1

The citations listed below are publications that use Tocris products. Selected citations for Demethylasterriquinone B1 include:

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Analytical SEC
By Anonymous on 12/20/2017
Species: Human

Bioassay development


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