Selective insulin receptor (IR) activator (EC50
values are 3 - 6 μ
M for IRTK and 100 μ
M for IGF1R and EGFR). Increases IR β
subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro
, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.
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All Tocris products are intended for laboratory research use only.
Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.
Kim et al.
A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells.
Weber et al.
Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator.
Webster et al.
Discovery of a small molecule insulin receptor activator.
Salituro et al.
Recent Prog.Horm.Res., 2001;56:107
The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors.
Wilkie et al.