Demethylasterriquinone B1

Tocris Bioscience | Catalog # 1819

Selective insulin RTK activator
Tocris Bioscience

Key Product Details

Description

Selective insulin RTK activator

Alternative Names

DAQ B1,L-783,281,DMAQ-B1
View all Insulin and Insulin-like Receptor Activators »

Product Description

Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Product Specifications for Demethylasterriquinone B1

Molecular Weight

506.59

Formula

C32H30N2O4

Storage

Desiccate at -20°C

Purity

≥95% (HPLC)

Chemical Name

2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione

CAS Number

78860-34-1

PubChem ID

3013166

InChI Key

XMGNJVXBPZAETK-UHFFFAOYSA-N

SMILES

CC(C)=CCC1=C2NC=C(C2=CC=C1)C1=C(O)C(=O)C(C2=C(NC3=CC=CC=C23)C(C)(C)C=C)=C(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.66 100

Preparing Stock Solutions for Demethylasterriquinone B1

The following data is based on the product molecular weight 506.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL
10 mM 0.20 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Demethylasterriquinone B1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Demethylasterriquinone B1

For research use only

Citations for Demethylasterriquinone B1

Customer Reviews for Demethylasterriquinone B1 (2)

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  • works well
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    10 μM
    Demethylasterriquinone B1 1819
  • Analytical SEC
    Name: Anonymous
    Verified Customer | Posted 12/20/2017
    Bioassay development
    Demethylasterriquinone B1 1819

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