Demethylasterriquinone B1

( 1 Review )    
Product Datasheet
Catalog Number:1819
Alternate Names:DAQ B1, L-783,281, DMAQ-B1
Chemical Name:2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
Product Details
Reviews
Biological Activity
Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.
Technical Data
  • M.Wt:
    506.59
  • Formula:
    C32H30N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    78860-34-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Average Rating: 4 (Based on 1 review)

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 Analytical SEC 1819 Array 1819
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  Human Anonymous 12/20/2017
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 Analytical SEC 1819
: Analytical SEC [1819].

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