des-His1-[Glu9]-Glucagon (1-29) amide

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2216/1
des-His1-[Glu9]-Glucagon (1-29) amide
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Description: Glucagon receptor antagonist
Product Details
Citations (1)
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Biological Activity

Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

Technical Data

M.Wt:
3358.68
Formula:
C148H221N41O47S
Sequence:
SQGTFTSEYSKYLDSRRAQDFVQWLMNT

(Modifications: Thr-28 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
110084-95-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.
    Unson et al.
    Peptides, 1989;10:1171
  2. Glucagon receptors on human islet cells contribute to glucose competence of Ins release.
    Huypens et al.
    Diabetologia, 2000;43:1012
  3. Synthetic peptide antagonists of glucagon.
    Unson et al.
    Proc.Natl.Acad.Sci.USA, 1987;84:4083

Product Datasheets

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Citation for des-His1-[Glu9]-Glucagon (1-29) amide

The citations listed below are publications that use Tocris products. Selected citations for des-His1-[Glu9]-Glucagon (1-29) amide include:

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