des-His¹-[Glu⁹]-Glucagon (1-29) amide

Name: des-His 1 -[Glu 9 ]-Glucagon (1-29) amide
Brand: Tocris Bioscience
SKU: 2216
Price: 450 USD
Availability: InStock

Tocris Bioscience | Catalog # 2216

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Citations (4)

Product Documents

Glucagon receptor antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Glucagon receptor antagonist

View all Glucagon Receptor Antagonists »

Product Description

des-His¹-[Glu⁹]-Glucagon (1-29) amide is a glucagon receptor antagonist (pA₂ = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

Product Specifications for des-His¹-[Glu⁹]-Glucagon (1-29) amide

Molecular Weight

3358.68

Formula

C₁₄₈H₂₂₁N₄₁O₄₇S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

110084-95-2

PubChem ID

16133829

InChI Key

RVXSASLSNHDASC-OSWDIKPLSA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

Concentration

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g/mol

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Huypens Glucagon receptors on human islet cells contribute to glucose competence of Ins release. Diabetologia 2000 PMID: 10990079
Unson Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA
Unson Biological activities of des-His¹[Glu⁹]glucagon amide, a glucagon antagonist. Peptides 1989 PMID: 2560175

Product Documents for des-His¹-[Glu⁹]-Glucagon (1-29) amide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for des-His¹-[Glu⁹]-Glucagon (1-29) amide

For research use only

Related Research Areas

Diabetes

Metabolic Peptide Hormones and Regulators

Citations for des-His¹-[Glu⁹]-Glucagon (1-29) amide

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