Biological ActivityGlucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.
(Modifications: Thr-28 = C-terminal amide)
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Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.
Unson et al.
Glucagon receptors on human islet cells contribute to glucose competence of Ins release.
Huypens et al.
Synthetic peptide antagonists of glucagon.
Unson et al.
Citation for des-His1-[Glu9]-Glucagon (1-29) amide
The citations listed below are publications that use Tocris products. Selected citations for des-His1-[Glu9]-Glucagon (1-29) amide include:
1 Citation: Showing 1 - 1
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
Authors: Weston Et al.
Acta Pharmacol Sin 2015;290:23009
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