Dexfenfluramine hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2695
Alternate Names:(+)-Fenfluramine
Chemical Name:(S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Product Details
Citations (3)
Reviews
Biological Activity
Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.
Technical Data
  • M.Wt:
    267.72
  • Formula:
    C12H16F3N.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    3239-45-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis
    Authors: Lyons Et al.
    The journal of Neuroscience  2016;36:7392
  2. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.
    Authors: Banas Et al.
    Neuropsychopharmacology  2011;36:423
  3. A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.
    Authors: Kiyasova Et al.
    J Neurosci  2011;31:2756

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