Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Biological ActivityIndirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine.
Higgins et al.
Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox.
Caccia et al.
Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice.
Bush et al.
Citations for Dexfenfluramine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:
4 Citations: Showing 1 - 4
Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.
Authors: Rodríguez-Muñoz Et al.
Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis
Authors: Lyons Et al.
The journal of Neuroscience 2016;36:7392
Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.
Authors: Banas Et al.
A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.
Authors: Kiyasova Et al.
J Neurosci 2011;31:2756
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