Catalog Number: 2695
Alternate Names: (+)-Fenfluramine
Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Biological Activity
Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.
Technical Data
  • M.Wt:
    267.72
  • Formula:
    C12H16F3N.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    3239-45-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine.
    Caccia et al.
    Pharmacol.Biochem.Behav., 1997;57:851
  2. Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine.
    Higgins et al.
    Br.J.Pharmacol., 2001;133:459
  3. Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice.
    Bush et al.
    Endocrine, 2006;29:375
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis
    Authors: Lyons Et al.
    The journal of Neuroscience 2016;36:7392
  2. A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.
    Authors: Kiyasova Et al.
    J Neurosci 2011;31:2756

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