DG 041

Tocris Bioscience | Catalog # 6240

Potent and selective EP3 antagonist; antiplatelet and antithrombotic
Tocris Bioscience

Key Product Details

Description

Potent and selective EP3 antagonist; antiplatelet and antithrombotic
View all Prostanoid Receptor Antagonists »

Product Description

DG 041 is a potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.

Product Specifications for DG 041

Molecular Weight

592.32

Formula

C23H15Cl4FN2O3S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide

CAS Number

861238-35-9

PubChem ID

11296282

InChI Key

BFBTVZNKWXWKNZ-HWKANZROSA-N

SMILES

CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.23 100

Preparing Stock Solutions for DG 041

The following data is based on the product molecular weight 592.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.44 mL 16.88 mL
5 mM 0.34 mL 1.69 mL 3.38 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for DG 041

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DG 041

For research use only

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