Catalog Number: 4454
Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Biological Activity
Nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).
Technical Data
  • M.Wt:
    318.13
  • Formula:
    C14H10Cl2NNaO2
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    15307-79-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
    Warner et al.
    Proc.Natl.Acad.Sci.USA, 1999;96:7563
  2. Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.
    Bort et al.
    J.Pharmacol.Exp.Ther., 1998;288:65
  3. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
    Laneuville et al.
    J.Pharmacol.Exp.Ther., 1994;271:927

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