Nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50
values are 0.075 μ
M for COX-1 and 0.038 μ
M for COX-2 in human whole blood assay).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
Warner et al.
Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.
Bort et al.
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
Laneuville et al.