Dihydrexidine hydrochloride

Tocris Bioscience | Catalog # 0884

Selective D1-like agonist
Tocris Bioscience

Key Product Details

Description

Selective D1-like agonist
View all Dopamine D1 and D5 Receptor Agonists »

Product Description

Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.

Licensing Information

Sold under license, US Patent 5,047,536

Product Specifications for Dihydrexidine hydrochloride

Molecular Weight

303.79

Formula

C17H17NO2.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride

CAS Number

137417-08-4

PubChem ID

11403931

InChI Key

IJYUPBNUPIRQEP-SATBOSKTSA-N

SMILES

OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.04 10
DMSO 15.19 50

Preparing Stock Solutions for Dihydrexidine hydrochloride

The following data is based on the product molecular weight 303.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.58 mL 32.92 mL 65.83 mL
2.5 mM 1.32 mL 6.58 mL 13.17 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for Dihydrexidine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Dihydrexidine hydrochloride

For research use only

Citations for Dihydrexidine hydrochloride

Customer Reviews for Dihydrexidine hydrochloride (1)

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  • Dose Response of Tango D1-bla Dopamine Receptor Signaling
    Name: Chandra Menendez
    Assay Type: In Vitro
    Cell Line/Tissue: Tango D1-bla U20S
    Verified Customer | Posted 08/20/2018
    I used this as our positive control when testing dose responses following treatment with our Tango D1-bla U20S cells to measure dopamine receptor 1 activity following treatment with Dihydrexidine.
    Dihydrexidine hydrochloride 0884

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