Dihydrexidine hydrochloride

  ( 4 citations )    
Product Datasheet
Catalog Number:0884
Chemical Name:(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Product Details
Citations (4)
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Reviews
Biological Activity
A potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.
Technical Data
  • M.Wt:
    303.79
  • Formula:
    C17H17NO2.HCl
  • Solubility:
    Soluble to 10 mM in water and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    158704-02-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license, US Patent 5,047,536
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dihydrexidine hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions.
    Authors: Parker and Kooi
    J Neurosci  2014;453:42525
  2. CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
    Authors: Urizar Et al.
    Anal Biochem  2011;7:624
  3. Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons.
    Authors: Smith Et al.
    Neuron  2005;45:765
  4. Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex.
    Authors: Gorelova Et al.
    J Neurophysiol  2002;88:3150

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