Dihydro-β-erythroidine hydrobromide

Key Product Details

Product Description

Dihydro-β-erythroidine hydrobromide is a member of the Erythrina alkaloids, it is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC₅₀ values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors, respectively). Antagonizes behavioral effects of nicotine in vivo. Dihydro-β-erythroidine blocks excitation of striatal GABAergic neurons, which completely suppress polysynaptic inhibition between striatal cholinergic interneurons. Dihydro-β-erythroidine hydrobromide has antidepressive-like effects in mice (forced swim and mouse suspension). Orally bioavailable.

Product Specifications for Dihydro-β-erythroidine hydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dihydro-β-erythroidine hydrobromide

The following data is based on the product molecular weight 356.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 72 publications citing the usage of this product.

• Andreasen Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests. J.Psychopharmacol. 2009 PMID: 18583432
• Dorst Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat.Commun 2020 PMID: 33037215
• Sullivan Recurrent Inhibitory Network among Striatal Cholinergic Interneurons. J.Neurosci. 2008 PMID: 18753369
• Harvey Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor α subunits. J.Neurochem. 1996 PMID: 8863500
• Damaj In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice. Psychopharmacology 1995 PMID: 7724704
• Williams and Robinson Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue. J.Neurosci. 1984 PMID: 6502210

Product Documents for Dihydro-β-erythroidine hydrobromide