Chemical Name: [1,1'-Biphenyl]-2,2'-diyliodonium chloride
Biological ActivityDiphenyleneiodonium chloride is a GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.
Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.
Ye et al.
Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitro and in vivo.
Wang et al.
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
Stuehr et al.
FASEB J., 1991;5:98
Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.
Yea et al.
Citations for Diphenyleneiodonium chloride
The citations listed below are publications that use Tocris products. Selected citations for Diphenyleneiodonium chloride include:
5 Citations: Showing 1 - 5
Role of miRNA-181a-2-3p in cadmium-induced inflammatory responses of human bronchial epithelial cells.
Authors: Kim Et al.
J Thorac Dis 2019;11:3055
Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
Authors: Gonsalves Et al.
Am J Hematol 2014;89:273
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
Authors: Leoni Et al.
J Clin Invest 2013;123:443
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
Authors: Knight Et al.
J Clin Invest 2013;123:2981
Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
Authors: Ruparel Et al.
Cancer Med 2012;153:2031
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