Diphenyleneiodonium chloride

  ( 4 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0504
Alternate Names:DPI
Chemical Name:[1,1'-Biphenyl]-2,2'-diyliodonium chloride
Product Details
Citations (4)
Reviews
Biological Activity
GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.
Technical Data
  • M.Wt:
    314.55
  • Formula:
    C12H8ClI
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at -20°C
  • CAS No:
    4673-26-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Diphenyleneiodonium chloride include:

4 Citations: Showing 1 - 4
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  1. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
    Authors: Gonsalves Et al.
    Am J Hematol  2014;89:273
  2. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest  2013;123:443
  3. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
    Authors: Knight Et al.
    J Clin Invest  2013;123:2981
  4. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
    Authors: Ruparel Et al.
    Cancer Med  2012;153:2031

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Average Rating: 5 (Based on 1 review)

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