Diphenyleneiodonium chloride

Tocris Bioscience | Catalog # 0504

GPR3 agonist; also inhibits NOS and NADPH oxidases
Tocris Bioscience

Key Product Details

Description

GPR3 agonist; also inhibits NOS and NADPH oxidases

Alternative Names

DPI
View all Additional Nitric Oxide Compounds »

Product Description

Diphenyleneiodonium chloride is a GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

Product Specifications for Diphenyleneiodonium chloride

Molecular Weight

314.55

Formula

C12H8ClI

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

[1,1'-Biphenyl]-2,2'-diyliodonium chloride

CAS Number

4673-26-1

PubChem ID

2733504

InChI Key

FCFZKAVCDNTYID-UHFFFAOYSA-M

SMILES

[Cl-].c1c2c3ccccc3[i+]c2ccc1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.14 10

Preparing Stock Solutions for Diphenyleneiodonium chloride

The following data is based on the product molecular weight 314.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.79 mL 158.96 mL 317.91 mL
0.5 mM 6.36 mL 31.79 mL 63.58 mL
1 mM 3.18 mL 15.90 mL 31.79 mL
5 mM 0.64 mL 3.18 mL 6.36 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Product Documents for Diphenyleneiodonium chloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Diphenyleneiodonium chloride

For research use only

Citations for Diphenyleneiodonium chloride

Customer Reviews for Diphenyleneiodonium chloride (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Diphenyleneiodonium chloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card
Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • a GPR3 agonist.
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/02/2018
    It is a GPR3 agonist and also inhibits NADPH oxidase. It increases cAMP in cultured astrocytes.

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All