GPR3 agonist (EC50
= 1 μ
M); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+
mobilization and β
-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.
Soluble to 10 mM in DMSO
Desiccate at -20°C
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All Tocris products are intended for laboratory research use only.
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
Stuehr et al.
FASEB J., 1991;5:98
Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.
Yea et al.
Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitro and in vivo.
Wang et al.
Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.
Ye et al.
The citations listed below are publications that use Tocris products. Selected citations for Diphenyleneiodonium chloride include:
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