Catalog Number: 0504
Alternate Names: DPI
Chemical Name: [1,1'-Biphenyl]-2,2'-diyliodonium chloride
Biological Activity
GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.
Technical Data
  • M.Wt:
    314.55
  • Formula:
    C12H8ClI
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    4673-26-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.
    Tew
    Biochemistry, 1993;32:10209
  2. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
    Stuehr et al.
    FASEB J., 1991;5:98
  3. Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.
    Yea et al.
    Biochem.J., 1990;265:95
  4. Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitro and in vivo.
    Wang et al.
    Br.J.Pharmacol., 1993;110:1232
  5. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.
    Ye et al.
    J.Pharmacol.Exp.Ther., 2014;349:437
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Diphenyleneiodonium chloride include:

4 Citations: Showing 1 - 4
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  1. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
    Authors: Gonsalves Et al.
    Am J Hematol 2014;89:273
  2. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest 2013;123:443
  3. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
    Authors: Knight Et al.
    J Clin Invest 2013;123:2981
  4. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
    Authors: Ruparel Et al.
    Cancer Med 2012;153:2031

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