Diphenyleneiodonium chloride

Catalog # Availability Size / Price Qty
0504/10
0504/50

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Diphenyleneiodonium chloride | CAS No. 4673-26-1 | Additional Nitric Oxide Compounds
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Description: GPR3 agonist; also inhibits NOS and NADPH oxidases
Alternative Names: DPI

Chemical Name: [1,1'-Biphenyl]-2,2'-diyliodonium chloride

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

Diphenyleneiodonium chloride is a GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

Technical Data

M.Wt:
314.55
Formula:
C12H8ClI
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
4673-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Diphenyleneiodonium chloride

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5 Citations: Showing 1 - 5

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