Diphenyleneiodonium chloride

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Diphenyleneiodonium chloride | CAS No. 4673-26-1 | Additional Nitric Oxide Compounds
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Description: GPR3 agonist; also inhibits NOS and NADPH oxidases
Alternative Names: DPI

Chemical Name: [1,1'-Biphenyl]-2,2'-diyliodonium chloride

Purity: ≥99%

Product Details
Citations (5)

Biological Activity

Diphenyleneiodonium chloride is a GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

Technical Data

Soluble to 10 mM in DMSO
Desiccate at -20°C

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Citations for Diphenyleneiodonium chloride

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