Catalog # Availability Size / Price Qty
Disulfiram | CAS No. 97-77-8 | Ca2+-ATPase Activators
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Description: Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities
Alternative Names: Tetraethylthiuram disulfide

Chemical Name: Bis(diethylthiocarbamyoyl)disulfide

Product Details
Citations (2)

Biological Activity

Disulfiram is an inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity. Pyroptosis inhibitor; binds gasdermin D (GSDMD) and inhibits pore formation. Also inhibits SARS-CoV-2 main protease (Mpro; IC50 = 9.35 μM) and inhibits viral replication in Vero cells in vitro.

Technical Data

Soluble to 20 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Disulfiram

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