Chemical Name: Bis(diethylthiocarbamyoyl)disulfide
Biological ActivityInhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.
Cho et al.
Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.
Johnson et al.
The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo.
Fisher et al.
Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disul.
Starling et al.
Citations for Disulfiram
The citations listed below are publications that use Tocris products. Selected citations for Disulfiram include:
2 Citations: Showing 1 - 2
Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.
Authors: Ahadome Et al.
JCI Insight 2016;1:e87001
HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells.
Authors: Chan Et al.
PLoS One 2016;13:1
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