Catalog Number: 3807
Alternate Names: Tetraethylthiuram disulfide
Chemical Name: Bis(diethylthiocarbamyoyl)disulfide
Biological Activity
Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.
Technical Data
  • M.Wt:
    296.54
  • Formula:
    C10H20N2S4
  • Solubility:
    Soluble to 20 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
    97-77-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram.
    Starling et al.
    Biochem.J., 1996;320:101
  2. Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.
    Cho et al.
    J.Biochem.Mol.Biol., 2007;40:1069
  3. Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.
    Johnson et al.
    Anal.Biochem., 2009;398:203
  4. The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo.
    Fisher et al.
    J.Pharmacol.Exp.Ther., 2010;332:326
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Disulfiram include:

1 Citations: Showing 1 - 1

  1. HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells.
    Authors: Chan Et al.
    PLoS One 2016;13:1

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