Disulfiram

Catalog # Availability Size / Price Qty
3807/50
Disulfiram | CAS No. 97-77-8 | Ca2+-ATPase Activators
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Description: Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities
Alternative Names: Tetraethylthiuram disulfide

Chemical Name: Bis(diethylthiocarbamyoyl)disulfide

Product Details
Citations (2)
Reviews (1)

Biological Activity

Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.

Technical Data

M.Wt:
296.54
Formula:
C10H20N2S4
Solubility:
Soluble to 20 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
97-77-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Disulfiram

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Irreversible inhibitor of Aldh1 with IC50 initial at 50 uM
By Anonymous on 10/26/2019
Species: Mouse

Recombinant Aldh1 was used in a standard fluorometric reporter assay with NAD+ as a cofactor, reaction velocity measured as relative changes in fluorescence. Disulfiram was added immediately prior to assessing activity. We noted decreasing velocity rates over time supporting this as a time-dependent/ irreversible inhibitor of Aldh enzymes.


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