(±)-AMG 487

Tocris Bioscience | Catalog # 4487

CXCR3 antagonist; inhibits cell migration and metastasis
Tocris Bioscience

Key Product Details

Description

CXCR3 antagonist; inhibits cell migration and metastasis
View all Chemokine Receptor Antagonists »

Product Description

(±)-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

Product Specifications for (±)-AMG 487

Molecular Weight

603.59

Formula

C32H28F3N5O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide

CAS Number

947536-03-0

PubChem ID

10282265

InChI Key

WQTKNBPCJKRYPA-UHFFFAOYSA-N

SMILES

CCOC(C=C3)=CC=C3N2C(C1=CC=CN=C1N=C2C(N(CC4=CC=CN=C4)C(CC5=CC=C(OC(F)(F)F)C=C5)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 60.36 100

Preparing Stock Solutions for (±)-AMG 487

The following data is based on the product molecular weight 603.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.28 mL 16.57 mL
5 mM 0.33 mL 1.66 mL 3.31 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 51 publications citing the usage of this product.

Product Documents for (±)-AMG 487

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (±)-AMG 487

For research use only

Customer Reviews for (±)-AMG 487 (1)

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  • AMG 487 reduces the symptoms and inflammation in interstitial cystitis.
    Name: Udai Singh
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    I used this product to reduce the activated CXCR3+ T cells in mouse with chronic interstitial cystitis.

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