(±)-J 113397

Key Product Details

Product Description

(±)-J 113397 is a potent and selective NOP receptor antagonist (IC₅₀ values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

Product Specifications for (±)-J 113397

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-J 113397

The following data is based on the product molecular weight 399.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.01 mL	25.03 mL	50.05 mL
2.5 mM	1.00 mL	5.01 mL	10.01 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

• Ozaki In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur.J.Pharmacol. 2000 PMID: 10940356
• Marti The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental Parkinsonism through overinhibition of nigrothalamic pathway. J.Neurosci. 2007 PMID: 17287504
• Kawamoto Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397). J.Med.Chem. 1999 PMID: 10602690

Product Documents for (±)-J 113397