(±)-trans-ACPD

Tocris Bioscience | Catalog # 0187

Group I and II mGlu agonist
Tocris Bioscience

Key Product Details

Description

Group I and II mGlu agonist
View all Group I mGluR Agonists »

Product Description

(±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective agonist for metabotropic glutamate receptors; active at both group I and group II mGlu receptors (EC50 values are 2, 15, 23 and ~800 μM at mGluR2, mGluR1, mGluR5 and mGluR4 respectively).

(1S,3R)-ACPD and cis-ACPD also available.

Product Specifications for (±)-trans-ACPD

Molecular Weight

173.17

Formula

C7H11NO4

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

(±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid

CAS Number

67684-64-4

PubChem ID

23789032

InChI Key

DXLSPTHQGVGVTN-NAAZMWONSA-N

SMILES

[H][C@@]1(CC[C@@](N)(C1)C(O)=O)C(O)=O.[H][C@]1(CC[C@](N)(C1)C(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5 with gentle warming
1eq. NaOH 8.66 50

Preparing Stock Solutions for (±)-trans-ACPD

The following data is based on the product molecular weight 173.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 11.55 mL 57.75 mL 115.49 mL
2.5 mM 2.31 mL 11.55 mL 23.10 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
25 mM 0.23 mL 1.15 mL 2.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

Product Documents for (±)-trans-ACPD

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (±)-trans-ACPD

For research use only

Citations for (±)-trans-ACPD

Customer Reviews for (±)-trans-ACPD (1)

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  • An mGluR agonist
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 02/21/2018
    trans-ACPD is mGluR agonist (Group I and II). We used at 100 microM in rat brain slices. It increases intracellular Ca2+ in astrocytes.

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