DLin-MC3-DMA

Name: DLin-MC3-DMA
Brand: Tocris Bioscience
SKU: 7946
Price: 341 USD
Availability: InStock

Tocris Bioscience | Catalog # 7946

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Product Documents

Component of lipid nanoparticles (LNPs); ionizable cationic lipid

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Component of lipid nanoparticles (LNPs); ionizable cationic lipid

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Product Description

DLin-MC3-DMA is an ionizable cationic lipid (pK_a = 6.44), used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for delivering cargos such as oligonucleotides into living cells. DLin-MC3-DMA can protect negatively charged cargos and facilitate their cytosolic transport.

This product is supplied pre-dissolved in anhydrous ethanol, 100mg/mL

For a fully formulated LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Product Specifications for DLin-MC3-DMA

Molecular Weight

642.09

Formula

C₄₃H₇₉NO₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

CAS Number

1224606-06-7

InChI Key

NRLNQCOGCKAESA-KWXKLSQISA-N

SMILES

C(OC(CCCN(C)C)=O)(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL)

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Semple Rational design of cationic lipids for siRNA delivery. Nat.Biotechnol 2010 PMID: 20081866
Jayaraman Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew.Chem.Int.Ed.Engl 2012 PMID: 22782619
Han An ionizable lipid toolbox for RNA delivery. Nat.Commun 2021 PMID: 34903741

Product Documents for DLin-MC3-DMA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for DLin-MC3-DMA

For research use only

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