Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Biological ActivityDMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
Jackson CS, Durandt C, Janse van Rensburg I et al.
Stem Cell Res.
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Jaakkola et al.
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne
Lomb et al.
Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury.
Barnucz et al.
Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
Ayrapetov et al.
PLoS One, 2011;6:e26064
Citation for DMOG
The citations listed below are publications that use Tocris products. Selected citations for DMOG include:
1 Citation: Showing 1 - 1
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Authors: Banh Et al.
Nat Cell Biol 2016;18:803
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To check the HIF2a activity in A549 cells.