Catalog Number: 4408
Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Biological Activity
Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions.
Technical Data
  • M.Wt:
    175.14
  • Formula:
    C6H9NO5
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    89464-63-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury.
    Barnucz et al.
    J.Pharmacol.Exp.Ther., 2013;345:25
  2. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola et al.
    Science, 2001;292:468
  3. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne
    Lomb et al.
    Mol.Pharmacol., 2009;75:1198
  4. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
    Ayrapetov et al.
    PLoS One, 2011;6:e26064

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