Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α
) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α
; promotes cell survival under hypoxic conditions.
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Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury.
Barnucz et al.
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Jaakkola et al.
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne
Lomb et al.
Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
Ayrapetov et al.
PLoS One, 2011;6:e26064