DMOG

Catalog # Availability Size / Price Qty
4408/10
4408/50
DMOG | CAS No. 89464-63-1 | Hydroxylase Inhibitors
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Description: Prolyl hydroxylase inhibitor

Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester

Purity: ≥97%

Product Details
Citations (3)
Reviews

Biological Activity

DMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.

Technical Data

M.Wt:
175.14
Formula:
C6H9NO5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
89464-63-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
    Jackson CS, Durandt C, Janse van Rensburg I et al.
    Stem Cell Res.
  2. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
    RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, W Zhang, A Sinha, CM Rose, M Isasa, S Zhang, R Wu, C Virtanen, T Hitomi, T Habu, SS Sidhu, A Koizumi, SE Wilkins, T Kislinger, SP Gygi, CJ Schofield, JW Dennis, BG Wouters, BG Neel
    Nat. Cell Biol, 2016;18(7):803-13.
  3. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

    Nat Cell Biol, 2016;18(7):803-13.
  4. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
    Robert S Banh
    Nat Cell Biol, 2016;18(7):803-13.
  5. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola et al.
    Science, 2001;292:468
  6. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne
    Lomb et al.
    Mol.Pharmacol., 2009;75:1198
  7. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury.
    Barnucz et al.
    J.Pharmacol.Exp.Ther., 2013;345:25
  8. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
    Ayrapetov et al.
    PLoS One, 2011;6:e26064

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Citations for DMOG

The citations listed below are publications that use Tocris products. Selected citations for DMOG include:

3 Citations: Showing 1 - 3

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