DMP-1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-89484

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
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Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: QYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DMP-1 Antibody - BSA Free

Immunohistochemistry-Paraffin: DMP-1 Antibody [NBP1-89484]

Immunohistochemistry-Paraffin: DMP-1 Antibody [NBP1-89484]

Immunohistochemistry-Paraffin: DMP-1 Antibody [NBP1-89484] - Staining of human breast shows strong nuclear positivity in glandular cells.

Applications for DMP-1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DMP-1

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Long Name

Dentin Matrix Protein 1

Alternate Names

DMP1

Gene Symbol

DMP1

Additional DMP-1 Products

Product Documents for DMP-1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for DMP-1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for DMP-1 Antibody - BSA Free

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Protocols

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FAQs for DMP-1 Antibody - BSA Free

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  • Q: Does NBP1-89484 have cross-reactivity with mouse/rat or not?

    A: NBP1-89484 has only been tested and validated for use in human tissues at this point. The % homology between human and mouse/rat is only around 63% which is low and we do not expect it to cross react.

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