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Structure for Dofetilide Cat No: 3757
Catalog Number: 3757
Alternate Names: Tikosyn, UK 68798
Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Biological Activity
Selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.
Technical Data
  • M.Wt:
    441.56
  • Formula:
    C19H27N3O5S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    115256-11-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. [3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel.
    Finlayson et al.
    Eur.J.Pharmacol., 2001;412:203
  2. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.
    Gwilt et al.
    J.Pharmacol.Exp.Ther., 1991;256:318
  3. Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofetilide.
    Carmeliet
    J.Pharmacol.Exp.Ther., 1992;262:809
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dofetilide include:

1 Citations: Showing 1 - 1

  1. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
    Authors: Bhave Et al.
    Mol Pharmacol 2011;79:42
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