Dofetilide

Tocris Bioscience | Catalog # 3757

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Tocris Bioscience

Key Product Details

Description

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Alternative Names

Tikosyn,UK 68798
View all Voltage-gated Potassium Channel Blockers »

Product Description

Dofetilide is a selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Dofetilide

Molecular Weight

441.56

Formula

C19H27N3O5S2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

CAS Number

115256-11-6

PubChem ID

71329

InChI Key

IXTMWRCNAAVVAI-UHFFFAOYSA-N

SMILES

CN(CCC2=CC=C(NS(=O)(C)=O)C=C2)CCOC1=CC=C(NS(=O)(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.16 100

Preparing Stock Solutions for Dofetilide

The following data is based on the product molecular weight 441.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for Dofetilide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Dofetilide

For research use only

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  • Dofetilide was used to study concentration dependent blocking action on brain Kv channels
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/31/2018
    Dofetilide was used to study concentration dependent blocking action on voltage gated potassium channels on human brain cells. Dofetilide showed increasing Kv channel blocking but at high concnetrations the blocking action is hampered.
    Dofetilide 3757

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