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Dofetilide

3757 3 Citations 1 Review Datasheet / COA / SDS
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3757/5
3757/25
Dofetilide | CAS No. 115256-11-6 | Voltage-gated Potassium Channel Blockers
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Description: KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Alternative Names: Tikosyn, UK 68798

Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

Purity: ≥99%

Product Details
Citations (3)
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.

Technical Data

M.Wt:
441.56
Formula:
C19H27N3O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
115256-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for Dofetilide

The citations listed below are publications that use Tocris products. Selected citations for Dofetilide include:

3 Citations: Showing 1 - 3

  1. Effects of UK 68798 and RS 43285 on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.
    Authors: Carstensen Et al.
    J Cardiovasc Electrophysiol  2019;30:596
  2. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  3. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
    Authors: Bhave Et al.
    Mol Pharmacol  2011;79:42

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Dofetilide was used to study concentration dependent blocking action on brain Kv channels
By Anonymous on 10/31/2018
Application: Species: Human

Dofetilide was used to study concentration dependent blocking action on voltage gated potassium channels on human brain cells. Dofetilide showed increasing Kv channel blocking but at high concnetrations the blocking action is hampered.

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