Selective potassium channel blocker. Blocks KV
11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+
). Displays class III antiarrhythmic properties.
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[3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel.
Finlayson et al.
UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.
Gwilt et al.
Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofetilide.
The citations listed below are publications that use Tocris products. Selected citations for Dofetilide include:
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