Dofetilide
Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Purity: ≥99%
Biological Activity
Dofetilide is a selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.
Gwilt et al.
J.Pharmacol.Exp.Ther., 1991;256:318 -
[3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel.
Finlayson et al.
Eur.J.Pharmacol., 2001;412:203 -
Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofet.
Carmeliet
J.Pharmacol.Exp.Ther., 1992;262:809
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Citations for Dofetilide
The citations listed below are publications that use Tocris products. Selected citations for Dofetilide include:
3 Citations: Showing 1 - 3
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Effects of UK 68798 and RS 43285 on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.
Authors: Carstensen Et al.
J Cardiovasc Electrophysiol 2019;30:596
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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
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Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
Authors: Bhave Et al.
Mol Pharmacol 2011;79:42
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Dofetilide was used to study concentration dependent blocking action on voltage gated potassium channels on human brain cells. Dofetilide showed increasing Kv channel blocking but at high concnetrations the blocking action is hampered.
