Selective potassium channel blocker. Blocks KV
11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+
). Displays class III antiarrhythmic properties.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
[3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel.
Finlayson et al.
UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.
Gwilt et al.
Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofetilide.
The citations listed below are publications that use Tocris products. Selected citations for Dofetilide include:
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