Chemical Name: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Biological ActivityReversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonize Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.
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Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.
Evans et al.
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