Dooku 1

Key Product Details

Product Description

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC₅₀ = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca²⁺-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Product Specifications for Dooku 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dooku 1

The following data is based on the product molecular weight 326.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.33 mL	30.66 mL
5 mM	0.61 mL	3.07 mL	6.13 mL
10 mM	0.31 mL	1.53 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Evans Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br.J.Pharmacol. 2018 PMID: 29498036

Product Documents for Dooku 1