Chemical Name: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Biological ActivityDooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.
Evans et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Dooku 1
There are currently no reviews for this product. Be the first to review Dooku 1 and earn rewards!
Have you used Dooku 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image