Dooku 1

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Dooku 1 | CAS No. 2253744-54-4 | Other Piezo Channel Compounds
1 Image
Description: Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity

Chemical Name: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole

Purity: ≥98%

Product Details

Biological Activity

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

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Tocris products are intended for laboratory research use only, unless stated otherwise.

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