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Yoda 1

Catalog #: 5586
5 Citations Datasheet / COA / SDS
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5586/50
Yoda 1 | CAS No. 448947-81-7 | Piezo Channel Activators
1 Image
Description: Piezo1 channel activator

Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca2+-dependent chromatin hypercondensation and alters Ca2+-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca2+ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca2+ influx and K+ and water efflux, causing shrinkage of the cells.

Technical Data

M.Wt:
355.27
Formula:
C13H8Cl2N4S2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
448947-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Yoda 1

The citations listed below are publications that use Tocris products. Selected citations for Yoda 1 include:

5 Citations: Showing 1 - 5

  1. Agonist-induced Piezo1 activation suppresses migration of transformed fibroblasts.
    Authors: Chubinskiy-Nadezhdin Et al.
    Biochem Biophys Res Commun.  2019;514:173
  2. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
    Authors: Romac Et al.
    Nat Commun  2018;9:1715
  3. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
    Authors: Tsuchiya
    Nat Commun  2018;9(1):2049
  4. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
    Authors: Dela Paz
    Biochem Biophys Res Commun  2018;497(1):220
  5. Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.
    Authors: Ilkan Et al.
    J Biol Chem  2017;292:9204

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