Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Biological ActivityPiezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemical activation of the mechanotransduction channel Piezo1.
Syeda et al.
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Mikhailov et al.
Citations for Yoda 1
The citations listed below are publications that use Tocris products. Selected citations for Yoda 1 include:
3 Citations: Showing 1 - 3
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
Authors: Romac Et al.
Nat Commun 2018;9:1715
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
Nat Commun 2018;9(1):2049
Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Authors: Dela Paz
Biochem Biophys Res Commun 2018;497(1):220
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Yoda 1
Average Rating: 5 (Based on 1 Review)
Have you used Yoda 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
We used to stimulate piezo1 receptor at around 1-10microM