Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Biological ActivityPiezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.
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Chemical activation of the mechanotransduction channel Piezo1.
Syeda et al.
Citations for Yoda 1
The citations listed below are publications that use Tocris products. Selected citations for Yoda 1 include:
2 Citations: Showing 1 - 2
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
Nat Commun 2018;9(1):2049
Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Authors: Dela Paz
Biochem Biophys Res Commun 2018;497(1):220
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We used to stimulate piezo1 receptor at around 1-10microM