Yoda 1 (CAS 448947-81-7): R&D Systems
Catalog Number: 5586
Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Biological Activity
Piezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.
Technical Data
  • M.Wt:
    355.27
  • Formula:
    C13H8Cl2N4S2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    448947-81-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical activation of the mechanotransduction channel Piezo1.
    Syeda et al.
    ELife, 2015;4:e07369

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