Catalog Number: 1431
Alternate Names: [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin
Biological Activity
Prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = D-Pen, Disulfide bridge between 2 - 5)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
    Chandrakumar et al.
    J.Med.Chem., 1992;35:2928
  2. [D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites.
    Clark et al.
    Eur.J.Pharmacol., 1986;128:303
  3. Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat.
    Fraser et al.
    J.Pharmacol.Exp.Ther., 2000;295:1135

The citations listed below are publications that use Tocris products. Selected citations for DPDPE include:

Showing Results 1 - 3 of 3

  1. Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
    Authors: Leal Et al.
    PLoS One
  2. Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
    Authors: Saloman Et al.
    Am J Physiol Heart Circ Physiol
  3. Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection.
    Authors: Peart Et al.
    J Mol Cell Cardiol
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