Prototypical selective δ
-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro
= 5.2 nM), and is antinociceptive in vivo
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Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Chandrakumar et al.
[D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites.
Clark et al.
Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat.
Fraser et al.
The citations listed below are publications that use Tocris products. Selected citations for DPDPE include:
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