Biological ActivityDPDPE is a prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
(Modifications: X = D-Pen, Disulfide bridge: 2-5)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
[D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites.
Clark et al.
Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Chandrakumar et al.
Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat.
Fraser et al.
Citations for DPDPE
The citations listed below are publications that use Tocris products. Selected citations for DPDPE include:
12 Citations: Showing 1 - 10
Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Authors: Nasrallah Et al.
Cell Rep 2019;27:86
Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Authors: Leroy Et al.
Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein.
Authors: Dunning Et al.
J Neurochem 2016;137:518
Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents.
Authors: Tsitoura Et al.
J Biol Chem 2015;290:7961
Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
Authors: Largent-Milnes Et al.
J Pharmacol Exp Ther 2013;347:7
Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
Authors: Leal Et al.
PLoS One 2013;305:H1246
Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.
Authors: Marti Et al.
Br J Pharmacol 2013;168:863
Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
Authors: Morse Et al.
BMC Pharmacol Toxicol 2013;14:17
Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
Authors: Morse Et al.
PLoS One 2011;6:e25643
Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
Authors: Saloman Et al.
Am J Physiol Heart Circ Physiol 2011;190:379
Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition.
Authors: Niu Et al.
Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection.
Authors: Peart Et al.
J Mol Cell Cardiol 2007;42:972
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