( 9 citations )    
Product Datasheet
Catalog Number:1431
Alternate Names:[D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin
Chemical Name:
Product Details
Citations (9)
Supplemental Products
Biological Activity
Prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = D-Pen, Disulfide bridge between 2 - 5)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for DPDPE include:

9 Citations: Showing 1 - 9
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  1. Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein.
    Authors: Dunning Et al.
    J Neurochem  2016;137:518
  2. Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents.
    Authors: Tsitoura Et al.
    J Biol Chem  2015;290:7961
  3. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
    Authors: Largent-Milnes Et al.
    J Pharmacol Exp Ther  2013;347:7
  4. Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
    Authors: Leal Et al.
    PLoS One  2013;305:H1246
  5. Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.
    Authors: Marti Et al.
    Br J Pharmacol  2013;168:863
  6. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  7. Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
    Authors: Saloman Et al.
    Am J Physiol Heart Circ Physiol  2011;190:379
  8. Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition.
    Authors: Niu Et al.
    Neuroscience  2011;180:344
  9. Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection.
    Authors: Peart Et al.
    J Mol Cell Cardiol  2007;42:972


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