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Description: Selective δ agonist
Alternative Names: [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin

Purity: ≥95%

Product Details
Citations (12)
Supplemental Products

Biological Activity

DPDPE is a prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.

Technical Data


(Modifications: X = D-Pen, Disulfide bridge: 2-5)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for DPDPE

The citations listed below are publications that use Tocris products. Selected citations for DPDPE include:

12 Citations: Showing 1 - 10

  1. Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
    Authors: Nasrallah Et al.
    Cell Rep  2019;27:86
  2. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
    Authors: Leroy Et al.
    Neuron  2019;102:260
  3. Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein.
    Authors: Dunning Et al.
    J Neurochem  2016;137:518
  4. Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents.
    Authors: Tsitoura Et al.
    J Biol Chem  2015;290:7961
  5. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
    Authors: Largent-Milnes Et al.
    J Pharmacol Exp Ther  2013;347:7
  6. Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
    Authors: Leal Et al.
    PLoS One  2013;305:H1246
  7. Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.
    Authors: Marti Et al.
    Br J Pharmacol  2013;168:863
  8. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  9. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  10. Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
    Authors: Saloman Et al.
    Am J Physiol Heart Circ Physiol  2011;190:379


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